MPHOSPH10 M-phase phosphoprotein 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MPHOSPH10provided by HGNC
Official Full Name: M-phase phosphoprotein 10provided by HGNC
Primary source: HGNC:HGNC:7213
See related: Ensembl:ENSG00000124383 MIM:605503; AllianceGenome:HGNC:7213
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CT90; MPP10; MPP10P; PPP1R106
Summary: This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein associates with the U3 small nucleolar ribonucleoprotein 60-80S complexes and may be involved in pre-rRNA processing. [provided by RefSeq, Dec 2010]
Expression: Ubiquitous expression in esophagus (RPKM 13.3), prostate (RPKM 12.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p13.3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (71130634..71150101)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (71141674..71161134)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (71357764..71377231)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-144725 (e-PCR)
- UniSTS:172379

D2S1581E (e-PCR)
- UniSTS:150665

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA processing	NAS Non-traceable Author Statement more info	PubMed
involved_in RNA splicing	NAS Non-traceable Author Statement more info	PubMed
involved_in RNA splicing, via transesterification reactions	NAS Non-traceable Author Statement more info	PubMed
involved_in maturation of SSU-rRNA	NAS Non-traceable Author Statement more info	PubMed
involved_in ribosomal small subunit biogenesis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of Mpp10 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Mpp10 complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromosome	IDA Inferred from Direct Assay more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	IDA Inferred from Direct Assay more info	PubMed
part_of sno(s)RNA-containing ribonucleoprotein complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: U3 small nucleolar ribonucleoprotein protein MPP10

Names: U3 small nucleolar ribonucleoprotein; m phase phosphoprotein 10; protein phosphatase 1, regulatory subunit 106

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.