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    SLX9 Slx9p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852972, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SLX9
    Official Full Name
    Slx9p
    Primary source
    SGD:S000003313
    Locus tag
    YGR081C
    See related
    AllianceGenome:SGD:S000003313; FungiDB:YGR081C; VEuPathDB:YGR081C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables G-quadruplex DNA binding activity. Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and ribosomal small subunit export from nucleus. Located in nucleolus. Part of 90S preribosome and preribosome, small subunit precursor. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SLX9 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (643148..643780, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene twinfilin TWF1 Neighboring gene Tom20p Neighboring gene translation initiation factor eIF2B subunit delta

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Slx9p facilitates efficient ITS1 processing of pre-rRNA in Saccharomyces cerevisiae. Bax R, et al. RNA, 2006 Nov. PMID 17018574, Free PMC Article
    2. A Novel G-Quadruplex Binding Protein in Yeast-Slx9. Götz S, et al. Molecules, 2019 May 7. PMID 31067825, Free PMC Article
    3. Genome-wide mRNA surveillance is coupled to mRNA export. Hieronymus H, et al. Genes Dev, 2004 Nov 1. PMID 15489286, Free PMC Article
    4. A mutant plasma membrane protein is stabilized upon loss of Yvh1, a novel ribosome assembly factor. Liu Y, et al. Genetics, 2009 Mar. PMID 19114459, Free PMC Article
    5. Impact of the yeast S0/uS2-cluster ribosomal protein rpS21/eS21 on rRNA folding and the architecture of small ribosomal subunit precursors. Pöll G, et al. PLoS One, 2023. PMID 36996028, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables G-quadruplex DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal small subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of 90S preribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus HDA PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, small subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of preribosome, small subunit precursor IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Slx9p
    NP_011595.3
    • Nuclear export receptor for exportin Crm1p; required for pre-rRNA processing and nuclear export of pre-40S pre-ribosomal particles; associates with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; binds G-quadruplex (G4) structures in DNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      643148..643780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181210.3 → NP_011595.3  TPA: Slx9p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011595.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZV63, P53251
      UniProtKB/TrEMBL
      B3LIE5, B5VJ25, C7GXR0, C8Z8X5
      Conserved Domains (1) summary
      pfam15341
      Location:47 → 206
      SLX9; Ribosome biogenesis protein SLX9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53251.1

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