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    AIG1 androgen induced 1 [ Homo sapiens (human) ]

    Gene ID: 51390, updated on 10-Dec-2024

    Summary

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    Official Symbol
    AIG1provided by HGNC
    Official Full Name
    androgen induced 1provided by HGNC
    Primary source
    HGNC:HGNC:21607
    See related
    Ensembl:ENSG00000146416 MIM:608514; AllianceGenome:HGNC:21607
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AIG-1; dJ95L4.1
    Summary
    Enables hydrolase activity. Involved in long-chain fatty acid catabolic process. Located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver (RPKM 13.8), kidney (RPKM 9.3) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See AIG1 in Genome Data Viewer
    Location:
    6q24.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (143059213..143343883)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (144251637..144536274)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (143380350..143665020)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17621 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25189 Neighboring gene HIVEP2 divergent transcript Neighboring gene long intergenic non-protein coding RNA 1277 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:143323875-143325074 Neighboring gene MPRA-validated peak6176 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25191 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:143381022-143381960 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17624 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25193 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25194 Neighboring gene uncharacterized LOC124901416 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:143497835-143498335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25195 Neighboring gene Sharpr-MPRA regulatory region 5457 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:143609782-143610665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25196 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:143654104-143655303 Neighboring gene ribosomal protein L31 pseudogene 27 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25197 Neighboring gene uncharacterized LOC107986656 Neighboring gene PARL pseudogene 2 Neighboring gene C4orf46 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25198 Neighboring gene adenosine deaminase tRNA specific 2 Neighboring gene tubulin beta 8 class VIII pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning of androgen-inducible gene 1 (AIG1) from human dermal papilla cells. Seo J, et al. Mol Cells, 2001 Feb 28. PMID 11266118
    2. AIG1 affects in vitro and in vivo virulence in clinical isolates of Entamoeba histolytica. Nakada-Tsukui K, et al. PLoS Pathog, 2018 Mar. PMID 29554130, Free PMC Article
    3. AIG1 is a novel Pirh2-interacting protein that activates the NFAT signaling pathway. Wu G, et al. Front Biosci (Elite Ed), 2011 Jun 1. PMID 21622095
    4. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. Parsons WH, et al. Nat Chem Biol, 2016 May. PMID 27018888, Free PMC Article
    5. Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. Ellinghaus E, et al. Leukemia, 2012 May. PMID 22076464, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High AIG1 expression is associated with virulence in clinical isolates of Entamoeba histolytica.
      Title: AIG1 affects in vitro and in vivo virulence in clinical isolates of Entamoeba histolytica.
    2. These results indicate that AIG1 and ADTRP are founding members of an evolutionarily conserved class of transmembrane threonine hydrolases involved in bioactive lipid metabolism.
      Title: AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs.
    3. identified a novel Pirh2-interacting protein, AIG1, by yeast two-hybrid screening and confirmed its interaction with p53 both in vitro and in vivo
      Title: AIG1 is a novel Pirh2-interacting protein that activates the NFAT signaling pathway.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10485, DKFZp686F03136

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in long-chain fatty acid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    androgen-induced gene 1 protein
    Names
    FAHFA hydrolase AIG1
    fatty acid esters of hydroxy fatty acids hydrolase AIG1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286587.2 → NP_001273516.1  androgen-induced gene 1 protein isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has alternate 5' exon structure and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AF151861, AL023581, AL136116, BC025278, BG196820
      UniProtKB/TrEMBL
      Q53HV5
      Conserved Domains (1) summary
      pfam04750
      Location:2 → 209
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    2. NM_001286588.2 → NP_001273517.1  androgen-induced gene 1 protein isoform c

      See identical proteins and their annotated locations for NP_001273517.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks multiple 3' exons but contains an alternate 3' exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK298533, AL023581, BX640703, CA431282, DB154031
      Consensus CDS
      CCDS69215.1
      UniProtKB/Swiss-Prot
      Q9NVV5
      Related
      ENSP00000485875.1, ENST00000629020.2
      Conserved Domains (1) summary
      pfam04750
      Location:12 → 133
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    3. NM_001286589.2 → NP_001273518.1  androgen-induced gene 1 protein isoform d

      See identical proteins and their annotated locations for NP_001273518.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks multiple 3' exons but contains an alternate 3' exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK298533, BX640703, CA431282
      Consensus CDS
      CCDS69216.1
      UniProtKB/Swiss-Prot
      Q9NVV5
      Related
      ENSP00000473952.1, ENST00000494282.6
      Conserved Domains (1) summary
      pfam04750
      Location:12 → 134
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    4. NM_001363721.2 → NP_001350650.1  androgen-induced gene 1 protein isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (e) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AL023581, AL136116, AL391726
      Consensus CDS
      CCDS87450.1
      UniProtKB/TrEMBL
      A0A2R8YCJ8, Q53HV5
      Related
      ENSP00000493676.1, ENST00000646199.1
      Conserved Domains (1) summary
      pfam04750
      Location:12 → 219
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    5. NM_001366344.1 → NP_001353273.1  androgen-induced gene 1 protein isoform f precursor

      Status: VALIDATED

      Source sequence(s)
      AL023581, AL136116, AL391726
      UniProtKB/TrEMBL
      Q53HV5
      Conserved Domains (1) summary
      pfam04750
      Location:12 → 266
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    6. NM_001366345.1 → NP_001353274.1  androgen-induced gene 1 protein isoform g

      Status: VALIDATED

      Source sequence(s)
      AL023581, AL136116, AL391726
      UniProtKB/TrEMBL
      Q53HV5
      Conserved Domains (1) summary
      pfam04750
      Location:36 → 243
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    7. NM_001366346.1 → NP_001353275.1  androgen-induced gene 1 protein isoform h

      Status: VALIDATED

      Source sequence(s)
      AL023581, AL136116, AL391726
      UniProtKB/TrEMBL
      Q53HV5
      Conserved Domains (1) summary
      pfam04750
      Location:12 → 219
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    8. NM_001366347.1 → NP_001353276.1  androgen-induced gene 1 protein isoform i

      Status: VALIDATED

      Source sequence(s)
      AL023581, AL136116, AL391726
      Consensus CDS
      CCDS94014.1
      UniProtKB/TrEMBL
      Q53HV5
      Related
      ENSP00000275235.4, ENST00000275235.8
      Conserved Domains (1) summary
      pfam04750
      Location:12 → 219
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    9. NM_001366348.1 → NP_001353277.1  androgen-induced gene 1 protein isoform j

      Status: VALIDATED

      Source sequence(s)
      AL023581, AL136116, AL391726
      UniProtKB/TrEMBL
      Q53HV5
      Conserved Domains (1) summary
      pfam04750
      Location:12 → 219
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    10. NM_001366349.2 → NP_001353278.1  androgen-induced gene 1 protein isoform k

      Status: VALIDATED

      Source sequence(s)
      AL023581, AL136116, AL391726
      UniProtKB/TrEMBL
      Q53HV5
      Conserved Domains (1) summary
      pfam04750
      Location:12 → 219
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    11. NM_001366350.1 → NP_001353279.1  androgen-induced gene 1 protein isoform l

      Status: VALIDATED

      Source sequence(s)
      AL023581, AL136116, AL391726
      UniProtKB/TrEMBL
      Q53HV5
      Conserved Domains (1) summary
      pfam04750
      Location:12 → 219
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    12. NM_001366351.1 → NP_001353280.1  androgen-induced gene 1 protein isoform m

      Status: VALIDATED

      Source sequence(s)
      AL023581, AL136116, AL391726
      UniProtKB/TrEMBL
      Q53HV5
      Related
      ENSP00000356573.4, ENST00000367601.8
      Conserved Domains (1) summary
      pfam04750
      Location:8 → 215
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    13. NM_001366352.1 → NP_001353281.1  androgen-induced gene 1 protein isoform n

      Status: VALIDATED

      Source sequence(s)
      AL023581, AL136116, AL391726
      Conserved Domains (1) summary
      pfam04750
      Location:36 → 157
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    14. NM_001366353.1 → NP_001353282.1  androgen-induced gene 1 protein isoform o

      Status: VALIDATED

      Source sequence(s)
      AL023581, AL136116
      UniProtKB/TrEMBL
      Q53HV5
      Conserved Domains (1) summary
      pfam04750
      Location:12 → 185
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    15. NM_001366354.1 → NP_001353283.1  androgen-induced gene 1 protein isoform p

      Status: VALIDATED

      Source sequence(s)
      AL023581, AL136116, AL391726
      Conserved Domains (1) summary
      pfam04750
      Location:12 → 133
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    16. NM_001366355.1 → NP_001353284.1  androgen-induced gene 1 protein isoform q

      Status: VALIDATED

      Source sequence(s)
      AL023581, AL136116, AL391726
      Conserved Domains (1) summary
      pfam04750
      Location:12 → 167
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    17. NM_001366356.2 → NP_001353285.1  androgen-induced gene 1 protein isoform r precursor

      Status: VALIDATED

      Source sequence(s)
      AL023581, AL391726
      Conserved Domains (1) summary
      pfam04750
      Location:12 → 181
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    18. NM_001366357.1 → NP_001353286.1  androgen-induced gene 1 protein isoform s

      Status: VALIDATED

      Source sequence(s)
      AL023581, AL136116, AL391726
      UniProtKB/TrEMBL
      Q5T2H4
      Conserved Domains (1) summary
      pfam04750
      Location:12 → 172
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    19. NM_001366358.1 → NP_001353287.1  androgen-induced gene 1 protein isoform t

      Status: VALIDATED

      Source sequence(s)
      AL023581, AL136116, AL391726
      UniProtKB/TrEMBL
      Q5T2H0
      Related
      ENSP00000407817.1, ENST00000458219.1
      Conserved Domains (1) summary
      pfam04750
      Location:1 → 131
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    20. NM_001366359.2 → NP_001353288.1  androgen-induced gene 1 protein isoform u

      Status: VALIDATED

      Source sequence(s)
      AL023581, AL391726
      Conserved Domains (1) summary
      pfam04750
      Location:8 → 130
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    21. NM_001366361.1 → NP_001353290.1  androgen-induced gene 1 protein isoform v

      Status: VALIDATED

      Source sequence(s)
      AL136116, AL391726
      UniProtKB/TrEMBL
      Q5T2H0
      Conserved Domains (1) summary
      pfam04750
      Location:1 → 105
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    22. NM_001366362.1 → NP_001353291.1  androgen-induced gene 1 protein isoform w

      Status: VALIDATED

      Source sequence(s)
      AL023581
      Conserved Domains (1) summary
      pfam04750
      Location:36 → 71
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    23. NM_001366363.1 → NP_001353292.1  androgen-induced gene 1 protein isoform x

      Status: VALIDATED

      Source sequence(s)
      AL023581
      Consensus CDS
      CCDS94013.1
      UniProtKB/TrEMBL
      Q5THU2
      Related
      ENSP00000356568.1, ENST00000367596.5
      Conserved Domains (1) summary
      pfam04750
      Location:12 → 47
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    24. NM_016108.4 → NP_057192.2  androgen-induced gene 1 protein isoform a

      See identical proteins and their annotated locations for NP_057192.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AK298533, AL136116, BC025278, BG196820
      Consensus CDS
      CCDS5198.1
      UniProtKB/Swiss-Prot
      B4DPX2, C9J569, Q5T2H2, Q6N047, Q7Z378, Q8TB14, Q9NVV5, Q9Y3A9, Q9Y5B4
      UniProtKB/TrEMBL
      Q53HV5
      Related
      ENSP00000350509.4, ENST00000357847.9
      Conserved Domains (1) summary
      pfam04750
      Location:12 → 219
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    RNA

    1. NR_158896.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL023581, AL136116, AL391726

    2. NR_158960.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL023581, AL136116, AL391726

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      143059213..143343883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      144251637..144536274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NVV5.3 GenPept UniProtKB/Swiss-Prot:Q9NVV5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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