CFD1 iron-sulfur cluster assembly protein CFD1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CFD1
Official Full Name: iron-sulfur cluster assembly protein CFD1
Primary source: SGD:S000001265
Locus tag: YIL003W
See related: AllianceGenome:SGD:S000001265; FungiDB:YIL003W; VEuPathDB:YIL003W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: DRE3
Summary: Enables 4 iron, 4 sulfur cluster binding activity. Contributes to ATP hydrolysis activity. Involved in iron-sulfur cluster assembly and tRNA wobble uridine modification. Located in cytoplasm. Part of cytosolic [4Fe-4S] assembly scaffold complex. Orthologous to human NUBP2 (NUBP iron-sulfur cluster assembly factor 2, cytosolic). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CFD1 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (349122..350003)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the Nbp35-Cfd1 complex, Cfd1 protein binds ATP. Cfd1 protein is hydrolysis competent when bound to Nbp35.
Title: The Cfd1 Subunit of the Nbp35-Cfd1 Iron Sulfur Cluster Scaffolding Complex Controls Nucleotide Binding.
The Yeast Nbp35-Cfd1 Cytosolic Iron-Sulfur Cluster Scaffold Is an ATPase.
Title: The Yeast Nbp35-Cfd1 Cytosolic Iron-Sulfur Cluster Scaffold Is an ATPase.
a model in which Cfd1-Nbp35 interaction increases the lability of assembled FeS on the Nbp35 scaffold for transfer to target apo-FeS proteins.
Title: Interaction with Cfd1 increases the kinetic lability of FeS on the Nbp35 scaffold.
a model for the mode of Fe-S cluster coordination within the Cfd1-Nbp35 complex, explaining its specific properties as a Fe-S scaffold device.
Title: A bridging [4Fe-4S] cluster and nucleotide binding are essential for function of the Cfd1-Nbp35 complex as a scaffold in iron-sulfur protein maturation.
suggest that the Cfd1-Nbp35 complex functions as a novel scaffold for [Fe-S] cluster assembly in the eukaryotic cytosol
Title: The Cfd1-Nbp35 complex acts as a scaffold for iron-sulfur protein assembly in the yeast cytosol.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IDA Inferred from Direct Assay more info	PubMed
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
contributes_to ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP-dependent FeS chaperone activity	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in iron-sulfur cluster assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron-sulfur cluster assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in iron-sulfur cluster assembly	IEA Inferred from Electronic Annotation more info
involved_in iron-sulfur cluster assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA wobble uridine modification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic [4Fe-4S] assembly scaffold complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: iron-sulfur cluster assembly protein CFD1

NP_012263.1

Highly conserved iron-sulfur cluster binding protein; localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

349122..350003

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179353.1 → NP_012263.1 TPA: iron-sulfur cluster assembly protein CFD1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012263.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVS7, P40558

UniProtKB/TrEMBL

A6ZVR5, B3LTL2, B5VKT3, C7GJH5, C8ZAP6, N1P971

Conserved Domains (1) summary

pfam10609
Location:15 → 271

ParA; NUBPL iron-transfer P-loop NTPase