ARV1 sterol homeostasis protein ARV1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ARV1
Official Full Name: sterol homeostasis protein ARV1
Primary source: SGD:S000004232
Locus tag: YLR242C
See related: AllianceGenome:SGD:S000004232; FungiDB:YLR242C; VEuPathDB:YLR242C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable zinc ion binding activity. Involved in several processes, including intracellular lipid transport; membrane lipid biosynthetic process; and regulation of plasma membrane sterol distribution. Located in Golgi apparatus and cortical endoplasmic reticulum. Used to study developmental and epileptic encephalopathy 38 and lipid storage disease. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 38. Orthologous to human ARV1 (ARV1 homolog, fatty acid homeostasis modulator). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ARV1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (622918..623883, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cold-sensitive phenotypes of a yeast null mutant of ARV1 support its role as a GPI flippase.
Title: Cold-sensitive phenotypes of a yeast null mutant of ARV1 support its role as a GPI flippase.
The most liposensitive yeast strain arose due to deletion of the "ARE2 required for viability" (ARV1) gene, encoding an evolutionarily conserved, potential lipid transporter that localizes to the endoplasmic reticulum membrane.
Title: A functional, genome-wide evaluation of liposensitive yeast identifies the "ARE2 required for viability" (ARV1) gene product as a major component of eukaryotic fatty acid resistance.
Arv1 deficiency affects structure and homeostasis of plasma and ER membranes, and does not affect sterol transport between ER and plasma membrane.
Title: Arv1 regulates PM and ER membrane structure and homeostasis but is dispensable for intracellular sterol transport.
In the presence of drug, S. cerevisiae cells lacking Arv1 are unable to induce ERG gene expression, have an altered pleiotrophic drug response, and are defective in multi-drug resistance efflux pump expression
Title: Arv1 lipid transporter function is conserved between pathogenic and nonpathogenic fungi.
Yeast Arv1p is an important protein required for the delivery of an early gycosylphosphatidylinositol (GPI)intermediate, GlcN-acylPI, to the first mannosyltransferase of GPI synthesis in the endoplasmic reticulum lumen.
Title: Yeast ARV1 is required for efficient delivery of an early GPI intermediate to the first mannosyltransferase during GPI assembly and controls lipid flow from the endoplasmic reticulum.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in ER to Golgi ceramide transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in GPI anchor biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular sterol transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular sterol transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular sterol transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of plasma membrane sterol distribution	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of plasma membrane sterol distribution	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingolipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sterol import	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sterol import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in cortical endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in cortical endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sterol homeostasis protein ARV1

NP_013343.1

Cortical ER protein; implicated in the membrane insertion of tail-anchored C-terminal single transmembrane domain proteins; may function in transport of glycosylphosphatidylinositol intermediates into the ER lumen; required for normal intracellular sterol distribution; human ARV1, required for normal cholesterol and bile acid homeostasis, can complement yeast arv1 null mutant; human variant causing early onset epileptic encephalopathy is unable to rescue the yeast null