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    Dhx57 DExH-box helicase 57 [ Mus musculus (house mouse) ]

    Gene ID: 106794, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Dhx57provided by MGI
    Official Full Name
    DExH-box helicase 57provided by MGI
    Primary source
    MGI:MGI:2147067
    See related
    Ensembl:ENSMUSG00000035051 AllianceGenome:MGI:2147067
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable RNA binding activity and helicase activity. Predicted to be involved in chromatin looping and chromatin remodeling. Is expressed in central nervous system and retina. Orthologous to human DHX57 (DExH-box helicase 57). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 21.0), CNS E14 (RPKM 17.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dhx57 in Genome Data Viewer
    Location:
    17 E3; 17 50.63 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (80545733..80597620, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (80238304..80290476, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3216 Neighboring gene STARR-positive B cell enhancer ABC_E7559 Neighboring gene serine and arginine-rich splicing factor 7 Neighboring gene STARR-positive B cell enhancer ABC_E5631 Neighboring gene gem nuclear organelle associated protein 6 Neighboring gene tetratricopeptide repeat domain 39D Neighboring gene STARR-positive B cell enhancer ABC_E3217 Neighboring gene STARR-positive B cell enhancer ABC_E5632 Neighboring gene STARR-seq mESC enhancer starr_43307 Neighboring gene STARR-seq mESC enhancer starr_43308 Neighboring gene STARR-positive B cell enhancer ABC_E7560 Neighboring gene MORN repeat containing 2 Neighboring gene Rho guanine nucleotide exchange factor 33 Neighboring gene STARR-seq mESC enhancer starr_43309 Neighboring gene STARR-seq mESC enhancer starr_43310 Neighboring gene predicted gene 10190

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
    2. Proteomic and yeast 2-hybrid screens to identify PTEN binding partners. Tibarewal P, et al. Adv Biol Regul, 2024 Jan. PMID 37839992
    3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    4. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    5. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC77974

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative ATP-dependent RNA helicase DHX57
    Names
    DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 homolog
    DEAH box protein 57
    NP_001157231.1
    NP_001397255.1
    NP_001397256.1
    NP_001397257.1
    NP_945180.2
    XP_030105293.1
    XP_030105294.1
    XP_030105295.1
    XP_030105296.1
    XP_030105297.1
    XP_036016147.1
    XP_036016148.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163759.2 → NP_001157231.1  putative ATP-dependent RNA helicase DHX57 isoform 1

      See identical proteins and their annotated locations for NP_001157231.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC132910
      Consensus CDS
      CCDS50188.1
      UniProtKB/Swiss-Prot
      Q3TS93, Q6NZK4, Q6P1B4, Q6P5D3, Q8BI63, Q8BIA2, Q8R360
      Related
      ENSMUSP00000083742.4, ENSMUST00000086555.11
      Conserved Domains (3) summary
      COG1643
      Location:501 → 1298
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd14317
      Location:181 → 218
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam05773
      Location:246 → 419
      RWD; RWD domain

    2. NM_001410326.1 → NP_001397255.1  putative ATP-dependent RNA helicase DHX57 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132910
      UniProtKB/Swiss-Prot
      Q3TS93, Q6NZK4, Q6P1B4, Q6P5D3, Q8BI63, Q8BIA2, Q8R360

    3. NM_001410327.1 → NP_001397256.1  putative ATP-dependent RNA helicase DHX57 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132910

    4. NM_001410328.1 → NP_001397257.1  putative ATP-dependent RNA helicase DHX57 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC132910

    5. NM_198942.3 → NP_945180.2  putative ATP-dependent RNA helicase DHX57 isoform 2

      See identical proteins and their annotated locations for NP_945180.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC132910
      Consensus CDS
      CCDS28990.1
      UniProtKB/Swiss-Prot
      Q6P5D3
      Related
      ENSMUSP00000041069.8, ENSMUST00000038166.9
      Conserved Domains (3) summary
      COG1643
      Location:448 → 1245
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd14317
      Location:128 → 165
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam05773
      Location:193 → 366
      RWD; RWD domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      80545733..80597620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160255.1 → XP_036016148.1  putative ATP-dependent RNA helicase DHX57 isoform X7

      Conserved Domains (1) summary
      COG1643
      Location:82 → 548
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    2. XM_030249437.2 → XP_030105297.1  putative ATP-dependent RNA helicase DHX57 isoform X6

      Conserved Domains (1) summary
      COG1643
      Location:11 → 771
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    3. XM_030249433.2 → XP_030105293.1  putative ATP-dependent RNA helicase DHX57 isoform X3

      Conserved Domains (3) summary
      COG1643
      Location:432 → 1229
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd14317
      Location:112 → 149
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam05773
      Location:177 → 350
      RWD; RWD domain

    4. XM_030249436.1 → XP_030105296.1  putative ATP-dependent RNA helicase DHX57 isoform X4

      Conserved Domains (2) summary
      COG1643
      Location:272 → 1069
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam05773
      Location:17 → 190
      RWD; RWD domain

    5. XM_030249435.2 → XP_030105295.1  putative ATP-dependent RNA helicase DHX57 isoform X4

      Conserved Domains (2) summary
      COG1643
      Location:272 → 1069
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam05773
      Location:17 → 190
      RWD; RWD domain

    6. XM_030249434.2 → XP_030105294.1  putative ATP-dependent RNA helicase DHX57 isoform X3

      Conserved Domains (3) summary
      COG1643
      Location:432 → 1229
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd14317
      Location:112 → 149
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam05773
      Location:177 → 350
      RWD; RWD domain

    7. XM_036160254.1 → XP_036016147.1  putative ATP-dependent RNA helicase DHX57 isoform X5

      Related
      ENSMUST00000234733.2
      Conserved Domains (4) summary
      COG1643
      Location:501 → 1008
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd14317
      Location:181 → 218
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam05773
      Location:246 → 419
      RWD; RWD domain
      pfam18345
      Location:305 → 323
      zf_CCCH_4; Zinc finger domain

    RNA

    1. XR_003952074.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P5D3.2 GenPept UniProtKB/Swiss-Prot:Q6P5D3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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