Cacng2 calcium voltage-gated channel auxiliary subunit gamma 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cacng2provided by RGD
Official Full Name: calcium voltage-gated channel auxiliary subunit gamma 2provided by RGD
Primary source: RGD:71095
See related: EnsemblRapid:ENSRNOG00000065511 AllianceGenome:RGD:71095
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ipr328
Summary: Enables ionotropic glutamate receptor binding activity. Involved in several processes, including eye blink reflex; positive regulation of AMPA receptor activity; and positive regulation of protein localization to basolateral plasma membrane. Located in cell surface; cerebellar mossy fiber; and postsynaptic density membrane. Part of AMPA glutamate receptor complex. Biomarker of childhood absence epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 10. Orthologous to human CACNG2 (calcium voltage-gated channel auxiliary subunit gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 36.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (111451605..111579071, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (109572838..109698516, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (119228112..119353332, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Evidence indicates that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors (AMPARs) are important modulators of alcohol self-administration and relapse-like behavior.
Title: Potentiation of amygdala AMPA receptor activity selectively promotes escalated alcohol self-administration in a CaMKII-dependent manner.
Study elucidates structures of the GluA2-TARP gamma2 complex in the presence of the partial agonist kainate or the full agonist quisqualate together with a positive allosteric modulator or with quisqualate alone. Structural and computational analysis suggests the full agonist and modulator complex harbors an ion-permeable channel gate, providing the first view of an activated AMPA receptor.
Title: Activation and Desensitization Mechanism of AMPA Receptor-TARP Complex by Cryo-EM.
cryo-EM structure of the homomeric GluA2 AMPA receptor saturated with TARP gamma2 subunits, showing how the TARPs are arranged with four-fold symmetry around the ion channel domain and make extensive interactions with the M1, M2 and M4 transmembrane helices
Title: Architecture of fully occupied GluA2 AMPA receptor-TARP complex elucidated by cryo-EM.
elevated S-nitrosylation of stargazin contributes to AMPAR upregulation during cocaine sensitization selectively in the nucleus accumbens shell.
Title: AMPA receptor upregulation in the nucleus accumbens shell of cocaine-sensitized rats depends upon S-nitrosylation of stargazin.
A significant increase in Stargazin/Cacng2 expression is identified in the whole cerebellum.
Title: c-Fos, Arc, and stargazin expression in rat eyeblink conditioning.
Stargazin and AMPA receptor membrane targeting is altered in mutant rats, potentially contributing to hyperexcitability in somatosensory cortex, with a developmental time course that would suggest a role in the epilepsy phenotype.
Title: Stargazin and AMPA receptor membrane expression is increased in the somatosensory cortex of Genetic Absence Epilepsy Rats from Strasbourg.
Data show that S-nitrosylation of stargazin increases binding to the AMPAR subunit GluR1, causing increased surface expression of the AMPAR.
Title: S-nitrosylation of stargazin regulates surface expression of AMPA-glutamate neurotransmitter receptors.
Stargazin protein expression was also significantly increased in the somatosensory cortex after the onset of spontaneous seizures. The results are of significant importance as they show that an increase in stargazin expression may be pro-epileptic.
Title: Genetic absence epilepsy rats from Strasbourg have increased corticothalamic expression of stargazin.
Fusing the cytoplasmic C terminus of stargazin to the C-terminal domains of either GluR1 or the gonadotropin-releasing hormone receptor permits efficient trafficking from the endoplasmic reticulum and sorting to the basolateral membrane.
Title: The stargazin C terminus encodes an intrinsic and transferable membrane sorting signal.
is a critical substrate in the bidirectional control of synaptic strength, which is thought to underlie aspects of learning and memory
Title: Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cacng2 (e-PCR), detects polymorphism
- UniSTS:498999

BF388004 (e-PCR)
- UniSTS:244800

BF416002 (e-PCR)
- UniSTS:249190

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel regulator activity	NAS Non-traceable Author Statement more info	PubMed
enables channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ionotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in eye blink reflex	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within membrane depolarization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within membrane hyperpolarization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular junction development	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter receptor transport, postsynaptic endosome to lysosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of AMPA receptor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein localization to basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynaptic neurotransmitter receptor diffusion trapping	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynaptic neurotransmitter receptor diffusion trapping	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of AMPA receptor activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in transmission of nerve impulse	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmission of nerve impulse	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of AMPA glutamate receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of AMPA glutamate receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cerebellar mossy fiber	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in somatodendritic compartment	ISO Inferred from Sequence Orthology more info
part_of voltage-gated calcium channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: voltage-dependent calcium channel gamma-2 subunit

Names: TARP gamma-2; calcium channel, voltage-dependent, gamma subunit 2; neuronal voltage-gated calcium channel gamma-2 subunit; stargazin; transmembrane AMPAR regulatory protein gamma-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053351.2 → NP_445803.2 voltage-dependent calcium channel gamma-2 subunit

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q71RJ2

UniProtKB/TrEMBL

Q99PR9

Related

ENSRNOP00000085982.1, ENSRNOT00000106728.2

Conserved Domains (1) summary

pfam00822
Location:6 → 197

PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

111451605..111579071 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017595135.3 → XP_017450624.1 voltage-dependent calcium channel gamma-2 subunit isoform X1

UniProtKB/TrEMBL

Q99PR9

Conserved Domains (1) summary

cl21598
Location:1 → 174

PMP22_Claudin; PMP-22/EMP/MP20/Claudin family