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    AIF1 Aif1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855811, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AIF1
    Official Full Name
    Aif1p
    Primary source
    SGD:S000005357
    Locus tag
    YNR074C
    See related
    AllianceGenome:SGD:S000005357; FungiDB:YNR074C; VEuPathDB:YNR074C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CPD1
    Summary
    Predicted to enable electron-transferring-flavoprotein dehydrogenase activity; flavin adenine dinucleotide binding activity; and oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor. Involved in positive regulation of apoptotic process and response to singlet oxygen. Located in mitochondrion and nucleus. Orthologous to human AIFM2 (AIF family member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AIF1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (777602..778738, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene hexose transporter HXT17 Neighboring gene putative mannitol dehydrogenase Neighboring gene Cos10p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The anthracenedione compound bostrycin induces mitochondria-mediated apoptosis in the yeast Saccharomyces cerevisiae. Xu C, et al. FEMS Yeast Res, 2010 May. PMID 20345898
    2. Cdc73 is a major regulator of apoptosis-inducing factor 1 expression in Saccharomyces cerevisiae via H3K36 methylation. Saha N, et al. FEBS Lett, 2024 Mar. PMID 38467538
    3. Involvement of Aif1 in apoptosis triggered by lack of Hxk2 in the yeast Saccharomyces cerevisiae. Amigoni L, et al. FEMS Yeast Res, 2016 May. PMID 26895787
    4. CHCHD4 links AIF to the biogenesis of respiratory chain complex I. Modjtahedi N, et al. Mol Cell Oncol, 2016 Mar. PMID 27308594, Free PMC Article
    5. The phytopathogenic virulent effector protein RipI induces apoptosis in budding yeast Saccharomyces cerevisiae. Deng MY, et al. Toxicon, 2016 Oct. PMID 27616453

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cdc73 is a major regulator of apoptosis-inducing factor 1 expression in Saccharomyces cerevisiae via H3K36 methylation.
      Title: Cdc73 is a major regulator of apoptosis-inducing factor 1 expression in Saccharomyces cerevisiae via H3K36 methylation.
    2. An AIF1 deletion mutant was resistant to anacardic acid-induced cell death, suggesting a key role of Aif1. Overexpression of Aif1 made cells highly susceptible to anacardic acid, further confirming that Aif1 mediates anacardic acid-induced apoptosis.
      Title: Apoptosis-inducing factor (Aif1) mediates anacardic acid-induced apoptosis in Saccharomyces cerevisiae.
    3. Deletion of AIF1 in hxk2Delta cells enhances survival after induction of apoptosis with both H2O2 and acetic acid, rescues the reduction of both growth rate and cell size, abrogates both H2O2 and acetic acid-induced ROS accumulation and decreases cell death, suggesting that Aif1 might be involved in both H2O2 and acetic acid-induced cell death in hxk2Delta cells.
      Title: Involvement of Aif1 in apoptosis triggered by lack of Hxk2 in the yeast Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables electron-transferring-flavoprotein dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in respiratory electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to singlet oxygen IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Aif1p
    NP_014472.1
    • Mitochondrial cell death effector; translocates to the nucleus in response to apoptotic stimuli; triggers apoptosis in cells lacking HXK2; homolog of mammalian Apoptosis-Inducing Factor, putative reductase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      777602..778738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183251.1 → NP_014472.1  TPA: Aif1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014472.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1P9, P52923
      UniProtKB/TrEMBL
      A6ZSE8, B3LPH0, C7GKY8
      Conserved Domains (1) summary
      cl39093
      Location:21 → 293
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52923.1

    Gene LinkOut

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