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    PFY1 profilin [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854289, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PFY1
    Official Full Name
    profilin
    Primary source
    SGD:S000005648
    Locus tag
    YOR122C
    See related
    AllianceGenome:SGD:S000005648; FungiDB:YOR122C; VEuPathDB:YOR122C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CLS5; PRF1
    Summary
    Enables actin monomer binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and proline-rich region binding activity. Involved in intracellular transport; mitotic actomyosin contractile ring assembly; and regulation of actin filament organization. Located in cytosol. Used to study amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 18. Orthologous to human PFN4 (profilin family member 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PFY1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    2
    Sequence:
    Chromosome: XV; NC_001147.6 (552298..552887, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene protein kinase RIO1 Neighboring gene glycerol 2-dehydrogenase (NADP(+)) GCY1 Neighboring gene Leo1p Neighboring gene ubiquitin-specific protease UBP2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hypoallergenic profilin--a new way to identify allergenic determinants. Paulus KE, et al. FEBS J, 2012 Aug. PMID 22682106
    2. Rational diversification of a promoter providing fine-tuned expression and orthogonal regulation for synthetic biology. Blount BA, et al. PLoS One, 2012. PMID 22442681, Free PMC Article
    3. The intron-containing gene for yeast profilin (PFY) encodes a vital function. Magdolen V, et al. Mol Cell Biol, 1988 Dec. PMID 3072473, Free PMC Article
    4. Regulation of profilin localization in Saccharomyces cerevisiae by phosphoinositide metabolism. Ostrander DB, et al. J Biol Chem, 1995 Nov 10. PMID 7592954
    5. Yeast profilin mutants inhibit classical nuclear import and alter the balance between actin and tubulin levels. Stochaj U. Biochem Cell Biol, 2024 Apr 1. PMID 38048555

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Profilin's Affinity for Formin Regulates the Availability of Filament Ends for Actin Monomer Binding.
      Title: Profilin's Affinity for Formin Regulates the Availability of Filament Ends for Actin Monomer Binding.
    2. The authors demonstrate that Pfy1 promotes actin polymerization under conditions of oxidative stress, while Pkc1 induces actin polymerization and cell survival under all the conditions tested.
      Title: Two proteins from Saccharomyces cerevisiae: Pfy1 and Pkc1, play a dual role in activating actin polymerization and in increasing cell viability in the adaptive response to oxidative stress.
    3. Profilin controls the energetics of its interaction with nonhybrid actin, but interactions between actin subdomains 1 and 2 affect the topography of the profilin binding site.
      Title: Control of the ability of profilin to bind and facilitate nucleotide exchange from G-actin.
    4. The mechanism and biological interaction of profilin and SRV2 protein were studied.
      Title: Mechanism and biological role of profilin-Srv2/CAP interaction.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin monomer binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin monomer binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin monomer binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables proline-rich region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proline-rich region binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic actomyosin contractile ring assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of formin-nucleated actin cable assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of formin-nucleated actin cable assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sequestering of actin monomers IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sequestering of actin monomers IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sequestering of actin monomers IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    profilin
    NP_014765.3
    • Profilin; binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress; protein abundance increases in response to DNA replication stress; highly conserved protein; human PFN1 (profilin 1) complements temperature sensitive pfy1 mutants, PFN1 mutations are a rare cause of ALS

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      552298..552887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183541.3 → NP_014765.3  TPA: profilin [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014765.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2I0, P07274
      UniProtKB/TrEMBL
      A6ZNW9, B3LJG4, C8ZI84, G2WMZ7, N1NWL7
      Conserved Domains (1) summary
      pfam00235
      Location:1 → 123
      Profilin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07274.2

    Gene LinkOut

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