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    Calr calreticulin [ Mus musculus (house mouse) ]

    Gene ID: 12317, updated on 13-Jan-2025

    Summary

    Official Symbol
    Calrprovided by MGI
    Official Full Name
    calreticulinprovided by MGI
    Primary source
    MGI:MGI:88252
    See related
    Ensembl:ENSMUSG00000003814 AllianceGenome:MGI:88252
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CRT; Calregulin
    Summary
    Enables calcium ion binding activity; carbohydrate binding activity; and mRNA binding activity. Involved in several processes, including peptide antigen assembly with MHC class I protein complex; positive regulation of phagocytosis; and protein stabilization. Acts upstream of or within cortical actin cytoskeleton organization; positive regulation of non-canonical NF-kappaB signal transduction; and regulation of meiotic nuclear division. Located in endoplasmic reticulum; external side of plasma membrane; and extracellular space. Part of MHC class I peptide loading complex. Is expressed in several structures, including central nervous system; extraembryonic component; gut; placenta; and white fat. Used to study congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung cancer (multiple); and thrombocytosis. Orthologous to human CALR (calreticulin). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in placenta adult (RPKM 574.7), genital fat pad adult (RPKM 279.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Calr in Genome Data Viewer
    Location:
    8 C3; 8 41.21 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85568717..85573560, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84842088..84846931, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene DAN domain family member 5, BMP antagonist Neighboring gene growth arrest and DNA-damage-inducible, gamma interacting protein 1 Neighboring gene RAD23 homolog A, nucleotide excision repair protein Neighboring gene STARR-positive B cell enhancer ABC_E5027 Neighboring gene RIKEN cDNA 1700122E12 gene Neighboring gene STARR-positive B cell enhancer ABC_E564 Neighboring gene predicted gene 5911 Neighboring gene phenylalanyl-tRNA synthetase, alpha subunit Neighboring gene microRNA 7069

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (9)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 26
    Function Evidence Code Pubs
    enables calcium ion binding  
    enables calcium ion binding PubMed 
    enables calcium ion binding  
    enables carbohydrate binding PubMed 
    enables complement component C1q complex binding  
    enables complement component C1q complex binding  
    enables hormone binding  
    enables hormone binding  
    enables integrin binding  
    enables integrin binding  
    enables iron ion binding  
    enables iron ion binding  
    enables mRNA binding PubMed 
    enables mRNA binding  
    enables molecular sequestering activity  
    enables molecular sequestering activity  
    enables nuclear androgen receptor binding  
    enables nuclear androgen receptor binding  
    enables nuclear export signal receptor activity  
    enables nuclear export signal receptor activity  
    enables peptide binding  
    enables peptide binding  
    enables protein binding PubMed 
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    enables unfolded protein binding  
    Items 1 - 25 of 26
    Items 1 - 25 of 51
    Process Evidence Code Pubs
    involved_in ERAD pathway  
    involved_in cardiac muscle cell differentiation  
    involved_in cellular response to electrical stimulus  
    involved_in cellular response to lithium ion  
    involved_in cellular response to virus  
    involved_in cellular senescence PubMed 
    involved_in cellular senescence  
    acts_upstream_of_or_within cortical actin cytoskeleton organization PubMed 
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of intracellular steroid hormone receptor signaling pathway  
    involved_in negative regulation of intracellular steroid hormone receptor signaling pathway  
    involved_in negative regulation of neuron differentiation  
    involved_in negative regulation of neuron differentiation  
    involved_in negative regulation of retinoic acid receptor signaling pathway  
    involved_in negative regulation of retinoic acid receptor signaling pathway  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of translation  
    involved_in negative regulation of translation  
    involved_in negative regulation of trophoblast cell migration  
    involved_in negative regulation of trophoblast cell migration  
    involved_in peptide antigen assembly with MHC class I protein complex PubMed 
    involved_in peptide antigen assembly with MHC class I protein complex  
    involved_in positive regulation of cell cycle PubMed 
    acts_upstream_of positive regulation of cell cycle  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of dendritic cell chemotaxis  
    involved_in positive regulation of dendritic cell chemotaxis  
    involved_in positive regulation of endothelial cell migration  
    involved_in positive regulation of endothelial cell migration  
    involved_in positive regulation of gene expression PubMed 
    acts_upstream_of_or_within positive regulation of non-canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of phagocytosis PubMed 
    involved_in positive regulation of substrate adhesion-dependent cell spreading  
    involved_in positive regulation of substrate adhesion-dependent cell spreading  
    involved_in protein export from nucleus  
    involved_in protein export from nucleus  
    involved_in protein folding  
    involved_in protein folding  
    involved_in protein localization to nucleus PubMed 
    involved_in protein localization to nucleus  
    involved_in protein stabilization PubMed 
    acts_upstream_of_or_within regulation of meiotic nuclear division PubMed 
    involved_in response to biphenyl  
    involved_in response to estradiol  
    involved_in response to glycoside  
    involved_in response to peptide  
    involved_in response to testosterone  
    involved_in response to xenobiotic stimulus  
    involved_in spermatogenesis  
    Items 1 - 25 of 51
    Items 1 - 20 of 39
    Component Evidence Code Pubs
    part_of MHC class I peptide loading complex PubMed 
    part_of MHC class I peptide loading complex  
    located_in acrosomal vesicle  
    located_in acrosomal vesicle  
    located_in cell surface  
    located_in collagen-containing extracellular matrix  
    located_in collagen-containing extracellular matrix  
    located_in cortical granule  
    located_in cytolytic granule  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum lumen PubMed 
    located_in endoplasmic reticulum lumen  
    is_active_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum quality control compartment PubMed 
    located_in external side of plasma membrane PubMed 
    located_in extracellular region  
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in glutamatergic synapse  
    located_in membrane PubMed 
    located_in nuclear envelope  
    located_in nuclear envelope  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in phagocytic vesicle  
    located_in postsynapse  
    part_of protein-containing complex  
    located_in ribosome  
    located_in ribosome  
    located_in sarcoplasmic reticulum  
    located_in sarcoplasmic reticulum lumen  
    located_in smooth endoplasmic reticulum  
    located_in smooth endoplasmic reticulum  
    Items 1 - 20 of 39

    General protein information

    Preferred Names
    calreticulin
    Names
    CRP55
    ERp60
    HACBP
    endoplasmic reticulum resident protein 60

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007591.3NP_031617.1  calreticulin precursor

      See identical proteins and their annotated locations for NP_031617.1

      Status: VALIDATED

      Source sequence(s)
      AK075605, AK160197, BB727203, BY291864
      Consensus CDS
      CCDS22479.1
      UniProtKB/Swiss-Prot
      P14211, Q3TVD2
      UniProtKB/TrEMBL
      B2MWM9, Q3UWP8
      Related
      ENSMUSP00000003912.7, ENSMUST00000003912.7
      Conserved Domains (1) summary
      pfam00262
      Location:23332
      Calreticulin; Calreticulin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      85568717..85573560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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