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    KIP1 Kip1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852216, updated on 9-Dec-2024

    Summary

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    Official Symbol
    KIP1
    Official Full Name
    Kip1p
    Primary source
    SGD:S000000159
    Locus tag
    YBL063W
    See related
    AllianceGenome:SGD:S000000159; FungiDB:YBL063W; VEuPathDB:YBL063W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CIN9
    Summary
    Enables microtubule motor activity. Involved in 2-micrometer plasmid partitioning; initial mitotic spindle pole body separation; and microtubule depolymerization. Located in spindle microtubule. Human ortholog(s) of this gene implicated in microcephaly with or without chorioretinopathy, lymphedema, or mental retardation. Orthologous to human KIF11 (kinesin family member 11). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See KIP1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (101886..105221)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Sef1p Neighboring gene thioredoxin peroxidase PRX1 Neighboring gene Skt5p Neighboring gene Arf family guanine nucleotide exchange factor YEL1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kinesin-5 Kip1 is a bi-directional motor that stabilizes microtubules and tracks their plus-ends in vivo. Fridman V, et al. J Cell Sci, 2013 Sep 15. PMID 23868978
    2. Degradation of the kinesin Kip1p at anaphase onset is mediated by the anaphase-promoting complex and Cdc20p. Gordon DM, et al. Proc Natl Acad Sci U S A, 2001 Oct 23. PMID 11606759, Free PMC Article
    3. The kinesin-related protein Kip1p of Saccharomyces cerevisiae is bipolar. Gordon DM, et al. J Biol Chem, 1999 Oct 1. PMID 10497250
    4. Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly. Hoyt MA, et al. J Cell Biol, 1992 Jul. PMID 1618897, Free PMC Article
    5. Directionality of individual kinesin-5 Cin8 motors is modulated by loop 8, ionic strength and microtubule geometry. Gerson-Gurwitz A, et al. EMBO J, 2011 Nov 18. PMID 22101328, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clb2/Cdc28 drives spindle pole separation by direct phosphorylation of Kip1 and Cin8.
      Title: B-cyclin/CDKs regulate mitotic spindle assembly by phosphorylating kinesins-5 in budding yeast.
    2. Results show that the 2 micron plasmid of Saccharomyces cerevisiae uses the Kip1 motor, but not the functionally redundant Cin8 motor, for its precise nuclear localization and equal segregation.
      Title: The selfish yeast plasmid uses the nuclear motor Kip1p but not Cin8p for its localization and equal segregation.
    3. Study finds in budding yeast that the widely conserved kinesin-5 sliding motor proteins, Cin8p and Kip1p, mediate chromosome congression by suppressing kMT plus-end assembly of longer kinetochore microtubules.
      Title: Chromosome congression by Kinesin-5 motor-mediated disassembly of longer kinetochore microtubules.
    4. spindle elongation in anaphase in Saccharomyces cerevisiae cells mutated for the kinesin-5 motor protein Kip1
      Title: Slk19-dependent mid-anaphase pause in kinesin-5-mutated cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in 2-micrometer plasmid partitioning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in initial mitotic spindle pole body separation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in initial mitotic spindle pole body separation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid segregation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of kinesin complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Kip1p
    NP_009490.1
    • Kinesin-related motor protein; tracks plus-ends and stabilizes microtubules; required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      101886..105221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178303.1 → NP_009490.1  TPA: Kip1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009490.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPT7, P28742
      UniProtKB/TrEMBL
      B3LNJ8, B5VDS4, C8Z3T3
      Conserved Domains (2) summary
      TIGR01612
      Location:423 → 948
      235kDa-fam; reticulocyte binding/rhoptry protein
      cd01364
      Location:50 → 419
      KISc_BimC_Eg5; Kinesin motor domain, BimC/Eg5 spindle pole proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28742.1

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