ZTA1 NADPH:quinone reductase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: ZTA1
Official Full Name: NADPH:quinone reductase
Primary source: SGD:S000000250
Locus tag: YBR046C
See related: AllianceGenome:SGD:S000000250; FungiDB:YBR046C; VEuPathDB:YBR046C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 2-alkenal reductase [NAD(P)+] activity; NADPH:quinone reductase activity; and mRNA 3'-UTR AU-rich region binding activity. Involved in cellular response to oxidative stress. Located in cytoplasm and nucleus. Orthologous to human CRYZ (crystallin zeta). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Structural insights into the cofactor-assisted substrate recognition of yeast quinone oxidoreductase Zta1
Title: Structural insights into the cofactor-assisted substrate recognition of yeast quinone oxidoreductase Zta1.
Data show that human and yeast zeta-crystallins bind AU-rich elements in RNA.
Title: Human and yeast zeta-crystallins bind AU-rich elements in RNA.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 2-alkenal reductase [NAD(P)+] activity	IDA Inferred from Direct Assay more info	PubMed
enables NADPH binding	IBA Inferred from Biological aspect of Ancestor more info
enables NADPH:quinone reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NADPH:quinone reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables NADPH:quinone reductase activity	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR AU-rich region binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR AU-rich region binding	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed

NP_009602.1

NADPH-dependent quinone reductase; GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin

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The following sections contain reference sequences that belong to a specific genome build. Explain