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    NHP10 Nhp10p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851562, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NHP10
    Official Full Name
    Nhp10p
    Primary source
    SGD:S000002160
    Locus tag
    YDL002C
    See related
    AllianceGenome:SGD:S000002160; FungiDB:YDL002C; VEuPathDB:YDL002C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HMO2
    Summary
    Enables DNA end binding activity and heteroduplex DNA loop binding activity. Involved in chromatin remodeling; double-strand break repair; and telomere maintenance via recombination. Located in nucleus. Part of Ino80 complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; amyotrophic lateral sclerosis; and mitochondrial DNA depletion syndrome 15. Orthologous to human TFAM (transcription factor A, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NHP10 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (446967..447578, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene F1F0 ATP synthase subunit delta Neighboring gene kleisin alpha Neighboring gene Rmd1p Neighboring gene alpha,alpha-trehalase NTH1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heteroduplex DNA loop binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in double-strand break repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance via recombination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ino80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Ino80 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nhp10p
    NP_010282.3
    • Non-essential INO80 chromatin remodeling complex subunit; preferentially binds DNA ends, protecting them from exonucleatic cleavage; deletion affects telomere maintenance via recombination; related to mammalian high mobility group proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      446967..447578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180061.3 → NP_010282.3  TPA: Nhp10p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010282.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRY6, Q03435
      UniProtKB/TrEMBL
      A6ZXW4, B3LGR0, B5VFQ9, C7GXZ2, C8Z4R8, G2WCF2, N1PAB3
      Conserved Domains (1) summary
      COG5648
      Location:24 → 203
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03435.1

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