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    THI74 Thi74p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852048, updated on 9-Dec-2024

    Summary

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    Official Symbol
    THI74
    Official Full Name
    Thi74p
    Primary source
    SGD:S000002846
    Locus tag
    YDR438W
    See related
    AllianceGenome:SGD:S000002846; FungiDB:YDR438W; VEuPathDB:YDR438W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Located in mitochondrion. Orthologous to human SLC35F5 (solute carrier family 35 member F5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See THI74 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1338274..1339386)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene salt homeostasis regulator Neighboring gene phosphatidylinositol N-acetylglucosaminyltransferase GPI19 Neighboring gene Lrs4p Neighboring gene histone methyltransferase DOT1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic implication of a novel thiamine transporter in human hypertension. Zhang K, et al. J Am Coll Cardiol, 2014 Apr 22. PMID 24509276, Free PMC Article
    2. Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae. Mojzita D, et al. Mol Genet Genomics, 2006 Aug. PMID 16850348
    3. Noncanonical regulation of phosphatidylserine metabolism by a Sec14-like protein and a lipid kinase. Wang Y, et al. J Cell Biol, 2020 May 4. PMID 32303746, Free PMC Article
    4. The S. cerevisiae m6A-reader Pho92 promotes timely meiotic recombination by controlling key methylated transcripts. Scutenaire J, et al. Nucleic Acids Res, 2023 Jan 25. PMID 35934316, Free PMC Article
    5. Association of yeast Upf1p with direct substrates of the NMD pathway. Johansson MJ, et al. Proc Natl Acad Sci U S A, 2007 Dec 26. PMID 18087042, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Thi74p
    NP_010726.3
    • Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication; shows sequence homology to human gene SLC35F3, a thiamine transporter implicated in hypertension

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1338274..1339386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180746.3 → NP_010726.3  TPA: Thi74p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010726.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT65, Q04083
      UniProtKB/TrEMBL
      B3LFM1, C7GTP1, C8Z5Z8, N1P8X4
      Conserved Domains (1) summary
      COG0697
      Location:113 → 354
      RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04083.1

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