LIN9 lin-9 DREAM MuvB core complex component [Homo sapiens (human)] - Gene

Summary

Official Symbol: LIN9provided by HGNC
Official Full Name: lin-9 DREAM MuvB core complex componentprovided by HGNC
Primary source: HGNC:HGNC:30830
See related: Ensembl:ENSG00000183814 MIM:609375; AllianceGenome:HGNC:30830
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TGS; BARA; TGS1; TGS2; Lin-9; BARPsv
Summary: This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Expression: Broad expression in testis (RPKM 3.7), heart (RPKM 2.8) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q42.12

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (226231149..226309767, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (225419172..225497821, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (226418850..226497468, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LIN9 and NEK2 Are Core Regulators of Mitotic Fidelity That Can Be Therapeutically Targeted to Overcome Taxane Resistance.
Title: LIN9 and NEK2 Are Core Regulators of Mitotic Fidelity That Can Be Therapeutically Targeted to Overcome Taxane Resistance.
High LIN9 expression is associated with Triple-negative breast cancers.
Title: Mitotic Vulnerability in Triple-Negative Breast Cancer Associated with LIN9 Is Targetable with BET Inhibitors.
The MuvB multiprotein complex, together with B-MYB and FOXM1 (MMB-FOXM1) regulate the expression of mitotic kinesins in breast cancer cells.
Title: Central spindle proteins and mitotic kinesins are direct transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer cell lines and are potential targets for therapy.
LIN-9 phosphorylation on threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression.
Title: LIN-9 phosphorylation on threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression.
Results show that E7 interacts with the B-Myb, FoxM1 and LIN9 components of this activator complex, leading to cooperative transcriptional activation of mitotic genes in primary cells and E7 recruitment to the corresponding promoters.
Title: A functional interaction of E7 with B-Myb-MuvB complex promotes acute cooperative transcriptional activation of both S- and M-phase genes. (129 c).
Study links hTRM9L and tRNA modifications to inhibition of tumour growth via LIN9 and HIF1-alpha-dependent mechanisms.
Title: A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α.
inactivation of LIN9, a subunit of DREAM, results in premature senescence, which can be overcome by the SV40 large T (LT) antigen
Title: Loss of LIN9, a member of the DREAM complex, cooperates with SV40 large T antigen to induce genomic instability and anchorage-independent growth.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest.
The repressor complex that Mip/LIN-9 forms with p107 takes functional precedence over the transcriptional activation linked to the Mip/LIN-9 and B-Myb interaction.
Title: Mammalian Mip/LIN-9 interacts with either the p107, p130/E2F4 repressor complex or B-Myb in a cell cycle-phase-dependent context distinct from the Drosophila dREAM complex.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in reproductive process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of transcription repressor complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein lin-9 homolog

Names: TUDOR gene similar protein; beta subunit-associated regulator of apoptosis; lin-9 homolog; pRB-associated protein; rb related pathway actor; type I interferon receptor beta chain-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270409.1 → NP_001257338.1 protein lin-9 homolog isoform 2

See identical proteins and their annotated locations for NP_001257338.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.

Source sequence(s)

AF190323, AL359742, BC045625, BX284931

UniProtKB/TrEMBL

H7C4T7

Related

ENSP00000418121.1, ENST00000460719.5

Conserved Domains (1) summary

pfam06584
Location:108 → 212

DIRP; DIRP
NM_001270410.2 → NP_001257339.1 protein lin-9 homolog isoform 3

See identical proteins and their annotated locations for NP_001257339.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AF190323, AL359742, BC065302, BX284931

Consensus CDS

CCDS91164.1

UniProtKB/TrEMBL

H0Y322, Q6P142

Related

ENSP00000355773.2, ENST00000366808.6

Conserved Domains (1) summary

pfam06584
Location:75 → 179

DIRP; DIRP
NM_001366237.1 → NP_001353166.1 protein lin-9 homolog isoform 4

Status: REVIEWED

Source sequence(s)

AL359742, BX284931

UniProtKB/TrEMBL

H7C4T7

Conserved Domains (1) summary

pfam06584
Location:143 → 247

DIRP
NM_001366238.1 → NP_001353167.1 protein lin-9 homolog isoform 5

Status: REVIEWED

Source sequence(s)

AL359742, BX284931

UniProtKB/TrEMBL

H7C4T7

Conserved Domains (1) summary

pfam06584
Location:142 → 246

DIRP
NM_001366239.1 → NP_001353168.1 protein lin-9 homolog isoform 6

Status: REVIEWED

Source sequence(s)

AL359742, BX284931

UniProtKB/TrEMBL

H7C4T7

Conserved Domains (1) summary

pfam06584
Location:143 → 247

DIRP; DIRP
NM_001366240.1 → NP_001353169.1 protein lin-9 homolog isoform 7

Status: REVIEWED

Source sequence(s)

AL359742, BX284931

UniProtKB/TrEMBL

H7C4T7

Conserved Domains (1) summary

pfam06584
Location:34 → 138

DIRP
NM_001366241.1 → NP_001353170.1 protein lin-9 homolog isoform 3

Status: REVIEWED

Source sequence(s)

AL359742, BX284931

Consensus CDS

CCDS91164.1

UniProtKB/TrEMBL

H0Y322, Q6P142

Conserved Domains (1) summary

pfam06584
Location:75 → 179

DIRP; DIRP
NM_001366245.2 → NP_001353174.1 protein lin-9 homolog isoform 8

Status: REVIEWED

Source sequence(s)

AF190324, BX284931

Consensus CDS

CCDS91165.1

UniProtKB/Swiss-Prot

Q5TKA1, Q5U5L8, Q5U7E1, Q6PI55, Q6ZTV4, Q7Z3J1

UniProtKB/TrEMBL

Q6P142

Related

ENSP00000505590.1, ENST00000681046.1

Conserved Domains (1) summary

pfam06584
Location:127 → 231

DIRP; DIRP
NM_173083.3 → NP_775106.2 protein lin-9 homolog isoform 1

See identical proteins and their annotated locations for NP_775106.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).

Source sequence(s)

AF190323, AL359742, BC045625

Consensus CDS

CCDS1553.1

UniProtKB/TrEMBL

H7C4T7

Related

ENSP00000329102.5, ENST00000328205.9

Conserved Domains (1) summary

pfam06584
Location:143 → 247

DIRP; DIRP

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

226231149..226309767 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017001084.2 → XP_016856573.2 protein lin-9 homolog isoform X3

UniProtKB/TrEMBL

H7C4T7
XM_047418546.1 → XP_047274502.1 protein lin-9 homolog isoform X2

UniProtKB/TrEMBL

H7C4T7
XM_024446565.2 → XP_024302333.2 protein lin-9 homolog isoform X1

UniProtKB/TrEMBL

Q6P142
XM_047418553.1 → XP_047274509.1 protein lin-9 homolog isoform X6

UniProtKB/TrEMBL

H7C4T7
XM_006711767.5 → XP_006711830.1 protein lin-9 homolog isoform X5

See identical proteins and their annotated locations for XP_006711830.1

UniProtKB/TrEMBL

H0Y322, Q6P142

Conserved Domains (1) summary

pfam06584
Location:75 → 179

DIRP; DIRP
XM_047418556.1 → XP_047274512.1 protein lin-9 homolog isoform X7
XM_011544173.3 → XP_011542475.2 protein lin-9 homolog isoform X4

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

225419172..225497821 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054336155.1 → XP_054192130.1 protein lin-9 homolog isoform X3

UniProtKB/TrEMBL

H7C4T7
XM_054336154.1 → XP_054192129.1 protein lin-9 homolog isoform X2

UniProtKB/TrEMBL

H7C4T7
XM_054336153.1 → XP_054192128.1 protein lin-9 homolog isoform X1

UniProtKB/TrEMBL

Q6P142
XM_054336158.1 → XP_054192133.1 protein lin-9 homolog isoform X6

UniProtKB/TrEMBL

H7C4T7
XM_054336157.1 → XP_054192132.1 protein lin-9 homolog isoform X5

UniProtKB/TrEMBL

H0Y322, Q6P142
XM_054336156.1 → XP_054192131.1 protein lin-9 homolog isoform X4
XM_054336159.1 → XP_054192134.1 protein lin-9 homolog isoform X7