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    MARCHF3 membrane associated ring-CH-type finger 3 [ Homo sapiens (human) ]

    Gene ID: 115123, updated on 9-Dec-2024

    Summary

    Official Symbol
    MARCHF3provided by HGNC
    Official Full Name
    membrane associated ring-CH-type finger 3provided by HGNC
    Primary source
    HGNC:HGNC:28728
    See related
    Ensembl:ENSG00000173926 MIM:613333; AllianceGenome:HGNC:28728
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MARCH3; RNF173; MARCH-III
    Summary
    This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013]
    Expression
    Broad expression in testis (RPKM 2.7), heart (RPKM 1.5) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MARCHF3 in Genome Data Viewer
    Location:
    5q23.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (126867714..127030558, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (127387759..127550637, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (126203406..126366250, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23025 Neighboring gene RNA, U6 small nuclear 752, pseudogene Neighboring gene LMNB1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16284 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:126112589-126113389 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16287 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16288 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23028 Neighboring gene lamin B1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:126174548-126175292 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:126175293-126176035 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:126176780-126177522 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:126181005-126181974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:126183029-126183855 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:126211055-126211554 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:126231155-126231764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23032 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:126366588-126367132 Neighboring gene uncharacterized LOC105379163 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:126376473-126377316 Neighboring gene chromosome 5 open reading frame 63 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16290

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20096, MGC48332

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase MARCHF3
    Names
    E3 ubiquitin-protein ligase MARCH3
    RING finger protein 173
    RING-type E3 ubiquitin transferase MARCH3
    RING-type E3 ubiquitin transferase MARCHF3
    membrane associated ring finger 3
    membrane-associated RING-CH protein III
    membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
    NP_848545.1
    XP_011541433.1
    XP_016864504.1
    XP_054207529.1
    XP_054207530.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033192.1 RefSeqGene

      Range
      5251..168095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_178450.5NP_848545.1  E3 ubiquitin-protein ligase MARCHF3

      See identical proteins and their annotated locations for NP_848545.1

      Status: REVIEWED

      Source sequence(s)
      AC093532, AC137794, BC047569, DB455278
      Consensus CDS
      CCDS4141.1
      UniProtKB/Swiss-Prot
      A8K264, B9EJE7, Q86UD3
      Related
      ENSP00000309141.5, ENST00000308660.6
      Conserved Domains (1) summary
      cd16699
      Location:70120
      RING_CH-C4HC3_MARCH2_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH2, MARCH3, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      126867714..127030558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011543131.4XP_011541433.1  E3 ubiquitin-protein ligase MARCHF3 isoform X1

      See identical proteins and their annotated locations for XP_011541433.1

      Conserved Domains (1) summary
      smart00744
      Location:70117
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
    2. XM_017009015.2XP_016864504.1  E3 ubiquitin-protein ligase MARCHF3 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      127387759..127550637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351554.1XP_054207529.1  E3 ubiquitin-protein ligase MARCHF3 isoform X1

    2. XM_054351555.1XP_054207530.1  E3 ubiquitin-protein ligase MARCHF3 isoform X2