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    MND2 Mnd2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854843, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MND2
    Official Full Name
    Mnd2p
    Primary source
    SGD:S000001464
    Locus tag
    YIR025W
    See related
    AllianceGenome:SGD:S000001464; FungiDB:YIR025W; VEuPathDB:YIR025W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ubiquitin ligase inhibitor activity. Involved in deactivation of mitotic spindle assembly checkpoint; nuclear division; and regulation of protein metabolic process. Located in nucleus. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MND2 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (403659..404765)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Dal81p Neighboring gene Ina22p Neighboring gene tyrosine protein phosphatase YVH1 Neighboring gene allantoinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ama1p-activated anaphase-promoting complex regulates the destruction of Cdc20p during meiosis II. Tan GS, et al. Mol Biol Cell, 2011 Feb 1. PMID 21118994, Free PMC Article
    2. The Ras/cAMP pathway and the CDK-like kinase Ime2 regulate the MAPK Smk1 and spore morphogenesis in Saccharomyces cerevisiae. McDonald CM, et al. Genetics, 2009 Feb. PMID 19087957, Free PMC Article
    3. Mitotic phosphorylation of the anaphase-promoting complex inhibitory subunit Mnd2 is necessary for efficient progression through meiosis i. Torres MP, et al. J Biol Chem, 2007 Jun 15. PMID 17459880
    4. Mnd2, an essential antagonist of the anaphase-promoting complex during meiotic prophase. Penkner AM, et al. Cell, 2005 Mar 25. PMID 15797380
    5. The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation. Foster SA, et al. Mol Cell, 2012 Sep 28. PMID 22940250, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that mitotic phosphorylation of Mnd2 is necessary for anaphase-promoting complex-mediated progression beyond the first meiotic nuclear division.
      Title: Mitotic phosphorylation of the anaphase-promoting complex inhibitory subunit Mnd2 is necessary for efficient progression through meiosis i.
    2. The requirement of Mnd2p for anaphase-promoting complex/cyclosome function appears to be negligible under standard laboratory conditions.
      Title: In vivo characterization of the nonessential budding yeast anaphase-promoting complex/cyclosome components Swm1p, Mnd2p and Apc9p.
    3. Mnd2, a factor known to associate with APC components, prevents premature securin degradation in meiosis by APC(Ama1).
      Title: Mnd2, an essential antagonist of the anaphase-promoting complex during meiotic prophase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ubiquitin ligase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in deactivation of mitotic spindle assembly checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of anaphase-promoting complex-dependent catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein autoubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic metaphase/anaphase transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic metaphase/anaphase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle assembly checkpoint signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of anaphase-promoting complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of anaphase-promoting complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Mnd2p
    NP_012291.1
    • Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      403659..404765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179547.1 → NP_012291.1  TPA: Mnd2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012291.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVV6, P40577
      UniProtKB/TrEMBL
      C7GLT1, G2WFV3, N1P0R8
      Conserved Domains (1) summary
      pfam05841
      Location:8 → 136
      Apc15p; Apc15p protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40577.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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