UTR1 NADH/NAD(+) kinase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: UTR1
Official Full Name: NADH/NAD(+) kinase
Primary source: SGD:S000003810
Locus tag: YJR049C
See related: AllianceGenome:SGD:S000003810; FungiDB:YJR049C; VEuPathDB:YJR049C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables NAD+ kinase activity and NADH kinase activity. Involved in NADP biosynthetic process and intracellular iron ion homeostasis. Located in cytoplasm and nucleus. Orthologous to human NADK (NAD kinase). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

NAD kinase homologues, especially Pos5p, were critical for supplying NADP and then NADPH in peroxisomal matrix. NADP, which was supplied mainly by Utr1p, Pos5p and Yef1p.
Title: [The effect of NAD kinase homologues on the beta-oxidation of unsaturated fatty acids with the double bond at an even position in Saccharomyces cerevisiae].
Utr1 and Pos5 are responsible for essentially all NAD/NADH kinase activity in vivo
Title: Synthetic lethal and biochemical analyses of NAD and NADH kinases in Saccharomyces cerevisiae establish separation of cellular functions.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables NAD+ kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD+ kinase activity	IEA Inferred from Electronic Annotation more info
enables NADH kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NAD metabolic process	IEA Inferred from Electronic Annotation more info
involved_in NADP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in NADP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in NADP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed

NP_012583.1

ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication