Taar8a trace amine-associated receptor 8A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Taar8aprovided by MGI
Official Full Name: trace amine-associated receptor 8Aprovided by MGI
Primary source: MGI:MGI:2685076
See related: Ensembl:ENSMUSG00000096442 AllianceGenome:MGI:2685076
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm230; taR-8a
Summary: Predicted to enable trace-amine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human TAAR8 (trace amine associated receptor 8). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 10 A4; 10 11.42 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (23952398..23953432)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (24076500..24077534)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that TAARs were expressed only at trace amounts in most of the tissues, the exceptions being TAAR1 in stomach and testis and TAAR8a in intestine, spleen, and testis.
Title: Distribution of exogenous [125I]-3-iodothyronamine in mouse in vivo: relationship with trace amine-associated receptors.
Previous studies reported TAAR expression in brain. This paper found TAAR expression only in olfactory epithelial cells and that each TAAR detects a unique set of amine ligands. TAARs seem to function as a family of chemosensory receptors for amines.
Title: A second class of chemosensory receptors in the olfactory epithelium.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

Taar8a (e-PCR), detects polymorphism
- UniSTS:516842

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled amine receptor activity	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables trace-amine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables trace-amine receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	RCA inferred from Reviewed Computational Analysis more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	RCA inferred from Reviewed Computational Analysis more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: trace amine-associated receptor 8a

Names: mTaar8a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001010830.1 → NP_001010830.1 trace amine-associated receptor 8a

See identical proteins and their annotated locations for NP_001010830.1

Status: PROVISIONAL

Source sequence(s)

AY702337

Consensus CDS

CCDS23745.1

UniProtKB/Swiss-Prot

Q5QD07

Related

ENSMUSP00000062719.6, ENSMUST00000051133.6

Conserved Domains (2) summary

pfam00001
Location:48 → 312

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:42 → 287

7tm_4; Olfactory receptor