Steap2 six transmembrane epithelial antigen of prostate 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Steap2provided by MGI
Official Full Name: six transmembrane epithelial antigen of prostate 2provided by MGI
Primary source: MGI:MGI:1921301
See related: Ensembl:ENSMUSG00000015653 AllianceGenome:MGI:1921301
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: STMP; IPCA1; IPCA-1; STAMP1; PCANAP1; 4921538B17Rik
Summary: Enables cupric reductase (NADH) activity and ferric-chelate reductase (NADPH) activity. Acts upstream of or within transition metal ion transport. Located in endosome and plasma membrane. Is expressed in several structures, including brain; gut; metanephros; reproductive system; and respiratory system. Orthologous to human STEAP2 (STEAP2 metalloreductase). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Broad expression in kidney adult (RPKM 8.7), cerebellum adult (RPKM 4.9) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 A1; 5 3.18 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (5714829..5744649, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (5664829..5694649, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Unveiling the role of copper metabolism and STEAP2 in idiopathic pulmonary fibrosis molecular landscape.
Title: Unveiling the role of copper metabolism and STEAP2 in idiopathic pulmonary fibrosis molecular landscape.
Overexpressing six-transmembrane protein of prostate 2 (STAMP2) alleviates sepsis-induced acute lung injury probably by hindering M1 macrophage polarization via the NF-kappaB pathway.
Title: Overexpressing six-transmembrane protein of prostate 2 (STAMP2) alleviates sepsis-induced acute lung injury probably by hindering M1 macrophage polarization via the NF-κB pathway.
The conformational modulation of STEAP2 by the local membrane cholesterol content can therefore serve as a potential mechanism to modulate STEAP2 function in a compartment-restricted manner
Title: Membrane cholesterol modulates STEAP2 conformation during dynamic intracellular trafficking processes leading to broad subcellular distribution.
Stamp1 and Stamp2 play critical roles in adipogenesis, but through different mechanisms.
Title: Differential expression and function of stamp family proteins in adipocyte differentiation.
STEAPs may represent novel markers of mesenchymal stem cells in man as well as mice.
Title: Six-transmembrane epithelial antigen of the prostate (STEAP1 and STEAP2)-differentially expressed by murine and human mesenchymal stem cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW045895 (e-PCR)
- UniSTS:165381

AA957889 (e-PCR)
- UniSTS:226208

AI930049 (e-PCR)
- UniSTS:179130

RH135499 (e-PCR)
- UniSTS:142556

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cupric reductase (NADH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables cupric reductase (NADH) activity	IDA Inferred from Direct Assay more info	PubMed
enables ferric-chelate reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables ferric-chelate reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	ISO Inferred from Sequence Orthology more info
involved_in Golgi to plasma membrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in copper ion import	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within copper ion import	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within copper ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in endocytosis	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within iron ion import across cell outer membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within iron ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulated exocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to hormone	ISO Inferred from Sequence Orthology more info
involved_in response to hormone	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in trans-Golgi network transport vesicle	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network transport vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: metalloreductase STEAP2

NP_001096626.1

EC 1.16.1.-

NP_001096627.1

EC 1.16.1.-

NP_001272398.1

EC 1.16.1.-

NP_001272399.1

EC 1.16.1.-

NP_001272400.1

EC 1.16.1.-

NP_083010.2

EC 1.16.1.-

XP_011238977.1

EC 1.16.1.-

XP_030110704.1

EC 1.16.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001103156.2 → NP_001096626.1 metalloreductase STEAP2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).

Source sequence(s)

AC092404, AK015015, AK052981, CJ122203

Consensus CDS

CCDS39007.1

UniProtKB/Swiss-Prot

Q3TS12, Q8BWB6

UniProtKB/TrEMBL

B2RX33, D3Z1C4

Related

ENSMUSP00000015797.5, ENSMUST00000015797.11

Conserved Domains (2) summary

COG2085
Location:31 → 216

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:261 → 404

Ferric_reduct; Ferric reductase like transmembrane component
NM_001103157.2 → NP_001096627.1 metalloreductase STEAP2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).

Source sequence(s)

AC092404, AK015015, AK052981, AK086787, CJ101909, CJ122203

Consensus CDS

CCDS39007.1

UniProtKB/Swiss-Prot

Q3TS12, Q8BWB6

UniProtKB/TrEMBL

B2RX33, D3Z1C4

Related

ENSMUSP00000111085.3, ENSMUST00000115425.9

Conserved Domains (2) summary

COG2085
Location:31 → 216

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:261 → 404

Ferric_reduct; Ferric reductase like transmembrane component
NM_001285469.1 → NP_001272398.1 metalloreductase STEAP2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).

Source sequence(s)

AC092404

Consensus CDS

CCDS39007.1

UniProtKB/Swiss-Prot

Q3TS12, Q8BWB6

UniProtKB/TrEMBL

B2RX33, D3Z1C4

Related

ENSMUSP00000116910.2, ENSMUST00000148333.8

Conserved Domains (2) summary

COG2085
Location:31 → 216

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:261 → 404

Ferric_reduct; Ferric reductase like transmembrane component
NM_001285470.1 → NP_001272399.1 metalloreductase STEAP2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).

Source sequence(s)

AC092404, AK015015, AK162343, CJ122203

Consensus CDS

CCDS39007.1

UniProtKB/Swiss-Prot

Q3TS12, Q8BWB6

UniProtKB/TrEMBL

B2RX33, D3Z1C4

Related

ENSMUSP00000111084.3, ENSMUST00000115424.9

Conserved Domains (2) summary

COG2085
Location:31 → 216

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:261 → 404

Ferric_reduct; Ferric reductase like transmembrane component
NM_001285471.1 → NP_001272400.1 metalloreductase STEAP2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and contains an alternate splice site in the 3' terminal exon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC092404

Consensus CDS

CCDS71541.1

UniProtKB/TrEMBL

D3YUM6, D3Z1C4

Related

ENSMUSP00000111087.2, ENSMUST00000115427.8

Conserved Domains (3) summary

COG2085
Location:31 → 216

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:261 → 395

Ferric_reduct; Ferric reductase like transmembrane component

pfam03807
Location:33 → 118

F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
NM_028734.5 → NP_083010.2 metalloreductase STEAP2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).

Source sequence(s)

AC092404, AK015015, AK052981

Consensus CDS

CCDS39007.1

UniProtKB/Swiss-Prot

Q3TS12, Q8BWB6

UniProtKB/TrEMBL

B2RX33, D3Z1C4

Related

ENSMUSP00000111086.3, ENSMUST00000115426.9

Conserved Domains (2) summary

COG2085
Location:31 → 216

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:261 → 404

Ferric_reduct; Ferric reductase like transmembrane component

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

5714829..5744649 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254844.2 → XP_030110704.1 metalloreductase STEAP2 isoform X1

UniProtKB/Swiss-Prot

Q3TS12, Q8BWB6

UniProtKB/TrEMBL

B2RX33, D3Z1C4

Conserved Domains (2) summary

COG2085
Location:31 → 216

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:261 → 404

Ferric_reduct; Ferric reductase like transmembrane component
XM_011240675.4 → XP_011238977.1 metalloreductase STEAP2 isoform X1

UniProtKB/Swiss-Prot

Q3TS12, Q8BWB6

UniProtKB/TrEMBL

B2RX33, D3Z1C4

Conserved Domains (2) summary

COG2085
Location:31 → 216

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:261 → 404

Ferric_reduct; Ferric reductase like transmembrane component