Tdh L-threonine dehydrogenase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tdhprovided by MGI
Official Full Name: L-threonine dehydrogenaseprovided by MGI
Primary source: MGI:MGI:1926231
See related: Ensembl:ENSMUSG00000021953 AllianceGenome:MGI:1926231
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables L-threonine 3-dehydrogenase activity and identical protein binding activity. Involved in threonine catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; nervous system; nose; tail mesenchyme; and yolk sac endoderm. Orthologous to human TDH (L-threonine dehydrogenase (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in placenta adult (RPKM 17.3), stomach adult (RPKM 0.9) and 1 other tissue See more
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Genomic context

Location:: 14 D1; 14 33.31 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (63729796..63746541, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (63492347..63509092, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TDH, responsible for mitochondrial production of acetyl-CoA in mouse embryonic stem cells, and the acetyltransferase GCN5L1 cooperate to acetylate Lys501 in KBP, allowing its recognition by and degradation via Fbxo15, an F-box protein transcriptionally controlled by the pluripotency core factors and repressed following differentiation.
Title: The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells.
Data shsow that metabolic flux through the TDH pathway is required for the viability and self-renewal of ES cells.
Title: Targeted killing of a mammalian cell based upon its specialized metabolic state.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tdh (e-PCR), detects polymorphism
- UniSTS:516156

NoName (e-PCR)
- UniSTS:237208

PMC117216P1 (e-PCR)
- UniSTS:270320

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-threonine 3-dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-threonine 3-dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in L-threonine catabolic process to glycine	IEA Inferred from Electronic Annotation more info
involved_in threonine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within threonine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in threonine catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: L-threonine 3-dehydrogenase, mitochondrial

NP_067455.5

EC 1.1.1.103

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021480.5 → NP_067455.5 L-threonine 3-dehydrogenase, mitochondrial precursor

See identical proteins and their annotated locations for NP_067455.5

Status: VALIDATED

Source sequence(s)

AK077571, BC058860

Consensus CDS

CCDS27202.1

UniProtKB/Swiss-Prot

Q6PD91, Q8K3F7, Q9JLU3

Related

ENSMUSP00000022522.9, ENSMUST00000022522.15

Conserved Domains (2) summary

cd05272
Location:57 → 363

TDH_SDR_e; L-threonine dehydrogenase, extended (e) SDRs

COG0451
Location:84 → 363

WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]