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    Esyt1 extended synaptotagmin-like protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 23943, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Esyt1provided by MGI
    Official Full Name
    extended synaptotagmin-like protein 1provided by MGI
    Primary source
    MGI:MGI:1344426
    See related
    Ensembl:ENSMUSG00000025366 AllianceGenome:MGI:1344426
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mbc2; vp115; Fam62a
    Summary
    Predicted to enable several functions, including calcium ion binding activity; identical protein binding activity; and phospholipid binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including foregut; genitourinary system; nervous system; sensory organ; and spleen. Orthologous to human ESYT1 (extended synaptotagmin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in mammary gland adult (RPKM 71.2), subcutaneous fat pad adult (RPKM 68.6) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Esyt1 in Genome Data Viewer
    Location:
    10 D3; 10 76.85 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128346117..128361728, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128510248..128525859, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene Riken cDNA A430046D13 gene Neighboring gene STARR-positive B cell enhancer ABC_E8378 Neighboring gene myosin, light polypeptide 6B Neighboring gene microRNA 6916 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127962008-127962317 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127962362-127962471 Neighboring gene STARR-positive B cell enhancer ABC_E90 Neighboring gene STARR-positive B cell enhancer ABC_E3927 Neighboring gene STARR-positive B cell enhancer ABC_E8870 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127984844-127985032 Neighboring gene zinc finger CCCH type containing 10 Neighboring gene STARR-positive B cell enhancer ABC_E2973 Neighboring gene ribosomal protein L41

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and preliminary characterization of a 121 kDa protein with multiple predicted C2 domains. Morris NJ, et al. Biochim Biophys Acta, 1999 May 18. PMID 10350628
    2. Loss of Extended Synaptotagmins ESyt2 and ESyt3 does not affect mouse development or viability, but in vitro cell migration and survival under stress are affected. Herdman C, et al. Cell Cycle, 2014. PMID 25486202, Free PMC Article
    3. Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable and Fertile without Obvious Endoplasmic Reticulum Dysfunction. Sclip A, et al. PLoS One, 2016. PMID 27348751, Free PMC Article
    4. Cytosolic LPS-induced caspase-11 oligomerization and activation is regulated by extended synaptotagmin 1. Ma Y, et al. Cell Rep, 2023 Jul 25. PMID 37393619, Free PMC Article
    5. The atypical kinase Cdk5 is activated by insulin, regulates the association between GLUT4 and E-Syt1, and modulates glucose transport in 3T3-L1 adipocytes. Lalioti V, et al. Proc Natl Acad Sci U S A, 2009 Mar 17. PMID 19255425, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Insulin-activated Cdk5 phosphorylates E-Syt1, which associates with GLUT4
      Title: The atypical kinase Cdk5 is activated by insulin, regulates the association between GLUT4 and E-Syt1, and modulates glucose transport in 3T3-L1 adipocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (8)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylethanolamine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipid transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum-plasma membrane tethering IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intermembrane lipid transfer ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intermembrane lipid transfer ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    extended synaptotagmin-1
    Names
    E-Syt1
    family with sequence similarity 62 (C2 domain containing), member A
    membrane-bound C2 domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011843.2 → NP_035973.1  extended synaptotagmin-1

      Status: PROVISIONAL

      Source sequence(s)
      AC170752
      Consensus CDS
      CCDS24280.1
      UniProtKB/Swiss-Prot
      Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6
      Related
      ENSMUSP00000026427.7, ENSMUST00000026427.8
      Conserved Domains (4) summary
      cd04030
      Location:959 → 1084
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:469 → 573
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      cd08391
      Location:635 → 753
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:125 → 303
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      128346117..128361728 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U7R1.2 GenPept UniProtKB/Swiss-Prot:Q3U7R1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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