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    ERP44 endoplasmic reticulum protein 44 [ Sus scrofa (pig) ]

    Gene ID: 100192437, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ERP44provided by VGNC
    Official Full Name
    endoplasmic reticulum protein 44provided by VGNC
    Primary source
    VGNC:VGNC:87783
    See related
    Ensembl:ENSSSCG00000040634
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    TXNDC4
    Expression
    Ubiquitous expression in liver (RPKM 57.2), spleen (RPKM 43.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See ERP44 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 1 NC_010443.5 (241788801..241897432, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 1 NC_010443.4 (270077943..270216303, complement)

    Chromosome 1 - NC_010443.5Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 4 group A member 3 Neighboring gene syntaxin 17 Neighboring gene uterine plasmin/trypsin inhibitor pseudogene Neighboring gene inversin Neighboring gene testis expressed 10 Neighboring gene Myb/SANT DNA binding domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of the porcine Ero1L and ERp44 genes: potential roles in controlling energy metabolism. Long Q, et al. Gen Comp Endocrinol, 2011 Sep 1. PMID 21664357
    2. Peroxisome proliferator-activated receptor-gamma increases adiponectin secretion via transcriptional repression of endoplasmic reticulum chaperone protein ERp44. Long Q, et al. Endocrinology, 2010 Jul. PMID 20484463
    3. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
    4. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tissue distribution analysis of Ero1L and ERp44 genes revealed extremely high expression in adipose tissue, and the topology of their phylogenic tree indicates a high degree of conservation among different species.
      Title: Molecular cloning and characterization of the porcine Ero1L and ERp44 genes: potential roles in controlling energy metabolism.
    2. Results indicated that PPARgamma is an essential regulatory factor for the transcriptional activity of ERp44, which in turn controls the secretion of adiponectin.
      Title: Peroxisome proliferator-activated receptor-gamma increases adiponectin secretion via transcriptional repression of endoplasmic reticulum chaperone protein ERp44.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    endoplasmic reticulum resident protein 44
    Names
    thioredoxin domain containing 4 (endoplasmic reticulum)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001137629.1 → NP_001131101.1  endoplasmic reticulum resident protein 44 precursor

      See identical proteins and their annotated locations for NP_001131101.1

      Status: PROVISIONAL

      Source sequence(s)
      EU552933
      UniProtKB/TrEMBL
      A0A286ZMW0, A0A4X1VFK3, A0A8D0XN45, A0A8W4FCJ6, B6CVD6
      Related
      ENSSSCP00000032921.2, ENSSSCT00000052989.3
      Conserved Domains (4) summary
      cd02996
      Location:30 → 136
      PDI_a_ERp44; PDIa family, endoplasmic reticulum protein 44 (ERp44) subfamily; ERp44 is an ER-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain, similar to that of PDIa, with a CXFS motif followed by ...
      cd03070
      Location:144 → 231
      PDI_b_ERp44; PDIb family, ERp44 subfamily, first redox inactive TRX-like domain b; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif followed ...
      cd03072
      Location:245 → 355
      PDI_b'_ERp44; PDIb' family, ERp44 subfamily, second redox inactive TRX-like domain b'; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif ...
      pfam13848
      Location:167 → 350
      Thioredoxin_6; Thioredoxin-like domain

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010443.5 Reference Sscrofa11.1 Primary Assembly

      Range
      241788801..241897432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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