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    KAR5 Kar5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855087, updated on 9-Dec-2024

    Summary

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    Official Symbol
    KAR5
    Official Full Name
    Kar5p
    Primary source
    SGD:S000004669
    Locus tag
    YMR065W
    See related
    AllianceGenome:SGD:S000004669; FungiDB:YMR065W; VEuPathDB:YMR065W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FIG3
    Summary
    Involved in karyogamy involved in conjugation with cellular fusion. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See KAR5 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (399702..401216)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Rim9p Neighboring gene Aep1p Neighboring gene Sov1p Neighboring gene Ubx4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. KAR5 encodes a novel pheromone-inducible protein required for homotypic nuclear fusion. Beh CT, et al. J Cell Biol, 1997 Dec 1. PMID 9382856, Free PMC Article
    2. Dynamic assembly of brambleberry mediates nuclear envelope fusion during early development. Abrams EW, et al. Cell, 2012 Aug 3. PMID 22863006, Free PMC Article
    3. Prm3p is a pheromone-induced peripheral nuclear envelope protein required for yeast nuclear fusion. Shen S, et al. Mol Biol Cell, 2009 May. PMID 19297527, Free PMC Article
    4. Distinct roles for key karyogamy proteins during yeast nuclear fusion. Melloy P, et al. Mol Biol Cell, 2009 Sep. PMID 19570912, Free PMC Article
    5. Pheromone-regulated genes required for yeast mating differentiation. Erdman S, et al. J Cell Biol, 1998 Feb 9. PMID 9456310, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kar5p is required for multiple functions in both inner and outer nuclear envelope fusion in Saccharomyces cerevisiae
      Title: Kar5p is required for multiple functions in both inner and outer nuclear envelope fusion in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in karyogamy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in karyogamy involved in conjugation with cellular fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in karyogamy involved in conjugation with cellular fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in karyogamy involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear membrane fusion involved in karyogamy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear membrane fusion involved in karyogamy IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Kar5p
    NP_013781.1
    • Protein required for nuclear membrane fusion during karyogamy; localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; similar to zebrafish Brambleberry protein; expression of the gene is regulated by pheromone

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      399702..401216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182563.1 → NP_013781.1  TPA: Kar5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013781.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZMC4, D6VZN9, Q04746
      UniProtKB/TrEMBL
      B3LLV8, C7GL59, C8ZER7, N1NX86
      Conserved Domains (1) summary
      pfam04163
      Location:2 → 504
      Tht1; Tht1-like nuclear fusion protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04746.1

    Gene LinkOut

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