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    ZNF738 zinc finger protein 738 [ Homo sapiens (human) ]

    Gene ID: 148203, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF738provided by HGNC
    Official Full Name
    zinc finger protein 738provided by HGNC
    Primary source
    HGNC:HGNC:32469
    See related
    Ensembl:ENSG00000172687 AllianceGenome:HGNC:32469
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein polyubiquitination. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 1.4), lymph node (RPKM 1.2) and 23 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF738 in Genome Data Viewer
    Location:
    19p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (21359000..21388582)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (21497531..21527122)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (21541802..21571384)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene COX16 pseudogene 1 Neighboring gene vomeronasal 1 receptor 83 pseudogene Neighboring gene zinc finger protein 708 Neighboring gene NANOG hESC enhancer GRCh37_chr19:21500539-21501043 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:21510155-21510676 Neighboring gene BCL2 interacting protein 3 pseudogene 25 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14383 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21512069-21513057 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21540515-21541072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14385 Neighboring gene iron-sulfur cluster assembly 1 pseudogene 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:21579974-21580212 Neighboring gene zinc finger protein 493 Neighboring gene MPRA-validated peak3410 silencer Neighboring gene uncharacterized LOC105372321 Neighboring gene MPRA-validated peak3411 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:21643213-21643712 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21646023-21646921

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
    2. OpenCell: Endogenous tagging for the cartography of human cellular organization. Cho NH, et al. Science, 2022 Mar 11. PMID 35271311, Free PMC Article
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    4. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article
    5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 738
    Names
    protein ZNF738

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355237.2 → NP_001342166.1  zinc finger protein 738 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC010615, AC022432
      Consensus CDS
      CCDS92573.1
      UniProtKB/Swiss-Prot
      A8K4N7, Q8NE65
      UniProtKB/TrEMBL
      A0A804HJ59
      Related
      ENSP00000507366.1, ENST00000683779.1
      Conserved Domains (3) summary
      smart00349
      Location:35 → 95
      KRAB; krueppel associated box
      COG5048
      Location:149 → 374
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:290 → 310
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001355239.2 → NP_001342168.1  zinc finger protein 738 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC010615, AC022432
      Consensus CDS
      CCDS86732.1
      Related
      ENSP00000311957.3, ENST00000311015.7
      Conserved Domains (1) summary
      smart00349
      Location:35 → 95
      KRAB; krueppel associated box

    3. NM_001355240.2 → NP_001342169.1  zinc finger protein 738 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC010615, AC022432
      Consensus CDS
      CCDS86733.1
      UniProtKB/TrEMBL
      E9PE46, M0R0N2
      Related
      ENSP00000370252.4, ENST00000380870.8
      Conserved Domains (1) summary
      smart00349
      Location:35 → 95
      KRAB; krueppel associated box

    4. NM_001355241.2 → NP_001342170.1  zinc finger protein 738 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC010615, AC022432
      UniProtKB/TrEMBL
      M0R0N2
      Related
      ENSP00000471336.1, ENST00000597810.5
      Conserved Domains (1) summary
      smart00349
      Location:35 → 95
      KRAB; krueppel associated box

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      21359000..21388582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438272.1 → XP_047294228.1  zinc finger protein 738 isoform X1

      UniProtKB/TrEMBL
      M0R0N2

    2. XM_047438273.1 → XP_047294229.1  zinc finger protein 738 isoform X2

      UniProtKB/TrEMBL
      M0R0N2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      21497531..21527122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320000.1 → XP_054175975.1  zinc finger protein 738 isoform X1

      UniProtKB/TrEMBL
      M0R0N2

    2. XM_054320001.1 → XP_054175976.1  zinc finger protein 738 isoform X2

      UniProtKB/TrEMBL
      M0R0N2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NE65.2 GenPept UniProtKB/Swiss-Prot:Q8NE65

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials