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    DDI2 cyanamide hydratase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855381, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DDI2
    Official Full Name
    cyanamide hydratase
    Primary source
    SGD:S000005279
    Locus tag
    YNL335W
    See related
    AllianceGenome:SGD:S000005279; FungiDB:YNL335W; VEuPathDB:YNL335W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DDI3
    Summary
    Enables cyanamide hydratase activity. Involved in cyanamide metabolic process. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DDI2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (11452..12129)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Y' element ATP-dependent helicase protein 1 copy 6 Neighboring gene Cos1p Neighboring gene putative pyridoxal 5'-phosphate synthase Neighboring gene pyridoxine biosynthesis protein SNZ2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of Ddi2, a highly inducible detoxifying metalloenzyme from Saccharomyces cerevisiae. Li J, et al. J Biol Chem, 2019 Jul 5. PMID 31152065, Free PMC Article
    2. Two duplicated genes DDI2 and DDI3 in budding yeast encode a cyanamide hydratase and are induced by cyanamide. Li J, et al. J Biol Chem, 2015 May 15. PMID 25847245, Free PMC Article
    3. Transcriptomic and phenotypic analysis of the effects of T-2 toxin on Saccharomyces cerevisiae: evidence of mitochondrial involvement. Jossé L, et al. FEMS Yeast Res, 2011 Feb. PMID 21114626
    4. Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp. Fu Y, et al. Cell, 2008 May 16. PMID 18485869
    5. Global response of Saccharomyces cerevisiae to an alkylating agent. Jelinsky SA, et al. Proc Natl Acad Sci U S A, 1999 Feb 16. PMID 9990050, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DDI2/3 genes protect host cells from cyanamide toxicity.
      Title: Two duplicated genes DDI2 and DDI3 in budding yeast encode a cyanamide hydratase and are induced by cyanamide.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cyanamide hydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyanamide hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cyanamide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    cyanamide hydratase
    NP_014064.1
    • Cyanamide hydratase that detoxifies cyanamide; member of the HD domain metalloprotein superfamily; expression is induced over 100-fold by cyanamide and by SN2-type DNA alkylating agents such as MMS and DMA; induction decreased in rad6 and rad18 mutants; gene and protein are identical to DDI3 and Ddi3p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      11452..12129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183173.1 → NP_014064.1  TPA: cyanamide hydratase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014064.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTG9, P0CH63, P0CH64, P43543
      UniProtKB/TrEMBL
      B3LPG7, B5VQ88, C8ZBV9, N1P6I3
      Conserved Domains (1) summary
      TIGR03401
      Location:2 → 224
      cyanamide_fam; HD domain protein, cyanamide hydratase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CH63.1
    P0CH64.1

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