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    ZFYVE27 zinc finger FYVE-type containing 27 [ Homo sapiens (human) ]

    Gene ID: 118813, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZFYVE27provided by HGNC
    Official Full Name
    zinc finger FYVE-type containing 27provided by HGNC
    Primary source
    HGNC:HGNC:26559
    See related
    Ensembl:ENSG00000155256 MIM:610243; AllianceGenome:HGNC:26559
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPG33; PROTRUDIN
    Summary
    This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear. [provided by RefSeq, Mar 2010]
    Expression
    Ubiquitous expression in small intestine (RPKM 6.9), duodenum (RPKM 6.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZFYVE27 in Genome Data Viewer
    Location:
    10q24.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (97737128..97760895)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (98617284..98641047)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (99496885..99520652)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:99446822-99448021 Neighboring gene arginine vasopressin induced 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2685 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:99478816-99479636 Neighboring gene MARVEL domain containing 1 Neighboring gene Sharpr-MPRA regulatory region 11334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3859 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2686 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2687 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99519797-99520296 Neighboring gene Sharpr-MPRA regulatory region 10521 Neighboring gene Sharpr-MPRA regulatory region 10024 Neighboring gene secreted frizzled related protein 5 Neighboring gene uncharacterized LOC107984260 Neighboring gene GOLGA7B divergent transcript Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:99599631-99600830

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The role of ZFYVE27/protrudin in hereditary spastic paraplegia. Martignoni M, et al. Am J Hum Genet, 2008 Jul. PMID 18606302, Free PMC Article
    2. Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS. Petrova V, et al. Nat Commun, 2020 Nov 5. PMID 33154382, Free PMC Article
    3. ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in hereditary spastic paraplegia. Mannan AU, et al. Am J Hum Genet, 2006 Aug. PMID 16826525, Free PMC Article
    4. Protrudin-mediated ER-endosome contact sites promote MT1-MMP exocytosis and cell invasion. Pedersen NM, et al. J Cell Biol, 2020 Aug 3. PMID 32479595, Free PMC Article
    5. Role of spastin and protrudin in neurite outgrowth. Zhang C, et al. J Cell Biochem, 2012 Jul. PMID 22573551

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protrudin-mediated ER-endosome contact sites promote MT1-MMP exocytosis and cell invasion.
      Title: Protrudin-mediated ER-endosome contact sites promote MT1-MMP exocytosis and cell invasion.
    2. Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS.
      Title: Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS.
    3. Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation.
      Title: Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation.
    4. Protrudin modulates seizure activity through GABAA receptor regulation.
      Title: Protrudin modulates seizure activity through GABA(A) receptor regulation.
    5. SPG33 protein protrudin contains hydrophobic, intramembrane hairpin domains, interacts with tubular ER proteins, and functions in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections.
      Title: Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation.
    6. findings indicate that protrudin interacts with spastin and induces axon formation through its N-terminal domain. Moreover, protrudin and spastin may work together to play an indispensable role in motor axon outg
      Title: Role of spastin and protrudin in neurite outgrowth.
    7. Protrudin-KIF5 complex contributes to the vesicular transport in neurons.
      Title: Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation.
    8. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    9. VAP-A is an important regulator both of the subcellular localization of protrudin and of its ability to stimulate neurite outgrowth.
      Title: Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein.
    10. The role of ZFYVE27/protrudin in hereditary spastic paraplegia is reported.
      Title: The role of ZFYVE27/protrudin in hereditary spastic paraplegia.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Hereditary spastic paraplegia 33
    MedGen: C1853251 OMIM: 610244 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum tubular network formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum tubular network formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neurotrophin TRK receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurotrophin TRK receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of axon extension IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of axon extension ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum tubular network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum tubular network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in growth cone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in growth cone membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in recycling endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protrudin
    Names
    spastic paraplegia 33 protein
    zinc finger FYVE domain containing 27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017075.1 RefSeqGene

      Range
      5008..28775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001002261.4 → NP_001002261.1  protrudin isoform 1

      See identical proteins and their annotated locations for NP_001002261.1

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Consensus CDS
      CCDS31262.1
      UniProtKB/Swiss-Prot
      Q5T4F4
      Conserved Domains (1) summary
      cd15723
      Location:354 → 414
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    2. NM_001002262.4 → NP_001002262.1  protrudin isoform 3

      See identical proteins and their annotated locations for NP_001002262.1

      Status: REVIEWED

      Source sequence(s)
      AK074876, AL358938, AL561314, BC030621, BF063694, DC302372
      Consensus CDS
      CCDS31264.1
      UniProtKB/Swiss-Prot
      Q5T4F4
      Related
      ENSP00000353069.3, ENST00000359980.5
      Conserved Domains (1) summary
      cd15723
      Location:342 → 402
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    3. NM_001174119.2 → NP_001167590.1  protrudin isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Consensus CDS
      CCDS53562.1
      UniProtKB/Swiss-Prot
      Q5T4F4
      Related
      ENSP00000337993.7, ENST00000337540.11
      Conserved Domains (1) summary
      cd15723
      Location:310 → 370
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    4. NM_001174120.2 → NP_001167591.1  protrudin isoform 5

      See identical proteins and their annotated locations for NP_001167591.1

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Consensus CDS
      CCDS53563.1
      UniProtKB/Swiss-Prot
      Q5T4F4
      Related
      ENSP00000350148.4, ENST00000357540.8
      Conserved Domains (1) summary
      cd15723
      Location:256 → 316
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    5. NM_001174121.2 → NP_001167592.1  protrudin isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Consensus CDS
      CCDS53565.1
      UniProtKB/Swiss-Prot
      Q5T4F4
      Related
      ENSP00000359642.3, ENST00000370610.7
      Conserved Domains (1) summary
      cd15723
      Location:249 → 309
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    6. NM_001174122.2 → NP_001167593.1  protrudin isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Consensus CDS
      CCDS53564.1
      UniProtKB/Swiss-Prot
      Q5T4F4
      Related
      ENSP00000359646.3, ENST00000370613.7
      Conserved Domains (1) summary
      cd15723
      Location:224 → 284
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    7. NM_001385871.1 → NP_001372800.1  protrudin isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Consensus CDS
      CCDS31262.1
      Related
      ENSP00000409594.2, ENST00000423811.3
      Conserved Domains (1) summary
      cd15723
      Location:354 → 414
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    8. NM_001385875.1 → NP_001372804.1  protrudin isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Consensus CDS
      CCDS31263.1
      UniProtKB/Swiss-Prot
      B7Z3S0, B7Z404, B7Z626, G8JLC3, G8JLF0, J3KP98, Q5T4F1, Q5T4F2, Q5T4F3, Q5T4F4, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08
      Related
      ENSP00000506975.1, ENST00000684270.1
      Conserved Domains (1) summary
      cd15723
      Location:349 → 409
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    9. NM_001385876.1 → NP_001372805.1  protrudin isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:360 → 420
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    10. NM_001385877.1 → NP_001372806.1  protrudin isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:348 → 408
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    11. NM_001385878.1 → NP_001372807.1  protrudin isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:347 → 407
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    12. NM_001385879.1 → NP_001372808.1  protrudin isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:347 → 407
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    13. NM_001385880.1 → NP_001372809.1  protrudin isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Consensus CDS
      CCDS31264.1
      Conserved Domains (1) summary
      cd15723
      Location:342 → 402
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    14. NM_001385881.1 → NP_001372810.1  protrudin isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:342 → 402
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    15. NM_001385882.1 → NP_001372811.1  protrudin isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:347 → 389
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    16. NM_001385883.1 → NP_001372812.1  protrudin isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:342 → 384
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    17. NM_001385884.1 → NP_001372813.1  protrudin isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:342 → 384
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    18. NM_001385885.1 → NP_001372814.1  protrudin isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:322 → 382
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    19. NM_001385886.1 → NP_001372815.1  protrudin isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:315 → 375
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    20. NM_001385887.1 → NP_001372816.1  protrudin isoform 16

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:315 → 375
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    21. NM_001385888.1 → NP_001372817.1  protrudin isoform 16

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:315 → 375
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    22. NM_001385889.1 → NP_001372818.1  protrudin isoform 17

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:310 → 370
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    23. NM_001385890.1 → NP_001372819.1  protrudin isoform 18

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:286 → 346
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    24. NM_001385891.1 → NP_001372820.1  protrudin isoform 18

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:286 → 346
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    25. NM_001385892.1 → NP_001372821.1  protrudin isoform 19

      Status: REVIEWED

      Source sequence(s)
      AL358938
      UniProtKB/TrEMBL
      A0A0S2Z627
      Conserved Domains (1) summary
      cd15723
      Location:281 → 341
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    26. NM_001385893.1 → NP_001372822.1  protrudin isoform 20

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:279 → 339
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    27. NM_001385894.1 → NP_001372823.1  protrudin isoform 20

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:279 → 339
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    28. NM_001385895.1 → NP_001372824.1  protrudin isoform 20

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:279 → 339
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    29. NM_001385896.1 → NP_001372825.1  protrudin isoform 21

      Status: REVIEWED

      Source sequence(s)
      AL358938
      UniProtKB/TrEMBL
      A0A0S2Z5V0
      Conserved Domains (1) summary
      cd15723
      Location:274 → 334
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    30. NM_001385897.1 → NP_001372826.1  protrudin isoform 21

      Status: REVIEWED

      Source sequence(s)
      AL358938
      UniProtKB/TrEMBL
      A0A0S2Z5V0
      Conserved Domains (1) summary
      cd15723
      Location:274 → 334
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    31. NM_001385898.1 → NP_001372827.1  protrudin isoform 21

      Status: REVIEWED

      Source sequence(s)
      AL358938
      UniProtKB/TrEMBL
      A0A0S2Z5V0
      Conserved Domains (1) summary
      cd15723
      Location:274 → 334
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    32. NM_001385899.1 → NP_001372828.1  protrudin isoform 22

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:270 → 330
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    33. NM_001385900.1 → NP_001372829.1  protrudin isoform 22

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:270 → 330
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    34. NM_001385901.1 → NP_001372830.1  protrudin isoform 23

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:268 → 328
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    35. NM_001385902.1 → NP_001372831.1  protrudin isoform 23

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:268 → 328
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    36. NM_001385903.1 → NP_001372832.1  protrudin isoform 24

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:268 → 328
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    37. NM_001385904.1 → NP_001372833.1  protrudin isoform 24

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:268 → 328
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    38. NM_001385905.1 → NP_001372834.1  protrudin isoform 25

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:263 → 323
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    39. NM_001385906.1 → NP_001372835.1  protrudin isoform 26

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:263 → 323
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    40. NM_001385908.1 → NP_001372837.1  protrudin isoform 26

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:263 → 323
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    41. NM_001385911.1 → NP_001372840.1  protrudin isoform 27

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:261 → 321
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    42. NM_001385915.1 → NP_001372844.1  protrudin isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Consensus CDS
      CCDS53565.1
      Conserved Domains (1) summary
      cd15723
      Location:249 → 309
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    43. NM_001385916.1 → NP_001372845.1  protrudin isoform 28

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:231 → 291
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    44. NM_001385918.1 → NP_001372847.1  protrudin isoform 29

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:231 → 291
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    45. NM_001385919.1 → NP_001372848.1  protrudin isoform 30

      Status: REVIEWED

      Source sequence(s)
      AL358938
      Conserved Domains (1) summary
      cd15723
      Location:131 → 191
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    46. NM_144588.7 → NP_653189.3  protrudin isoform 2

      See identical proteins and their annotated locations for NP_653189.3

      Status: REVIEWED

      Source sequence(s)
      AK074876, AL358938, AL561314, BC030621, BF063694, DC302372
      Consensus CDS
      CCDS31263.1
      UniProtKB/Swiss-Prot
      B7Z3S0, B7Z404, B7Z626, G8JLC3, G8JLF0, J3KP98, Q5T4F1, Q5T4F2, Q5T4F3, Q5T4F4, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08
      Related
      ENSP00000377282.3, ENST00000393677.8
      Conserved Domains (1) summary
      cd15723
      Location:349 → 409
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    RNA

    1. NR_169794.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358938

    2. NR_169795.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358938

    3. NR_169796.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358938

    4. NR_169797.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358938

    5. NR_169798.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358938

    6. NR_169799.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358938

    7. NR_169800.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358938

    8. NR_169801.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358938

    9. NR_169802.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358938

    10. NR_169803.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358938

    11. NR_169804.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358938

    12. NR_169805.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358938

    13. NR_169806.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358938

    14. NR_169808.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358938

    15. NR_169809.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358938

    16. NR_169810.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358938

    17. NR_169811.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358938

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      97737128..97760895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539252.3 → XP_011537554.1  protrudin isoform X1

      Conserved Domains (1) summary
      cd15723
      Location:354 → 396
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    2. XM_011539253.3 → XP_011537555.1  protrudin isoform X2

      Conserved Domains (1) summary
      cd15723
      Location:347 → 389
      FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

    3. XM_017015646.2 → XP_016871135.1  protrudin isoform X5

      UniProtKB/TrEMBL
      B7Z6J9

    4. XM_017015644.1 → XP_016871133.1  protrudin isoform X3

    5. XM_017015645.1 → XP_016871134.1  protrudin isoform X4

    6. XM_047424567.1 → XP_047280523.1  protrudin isoform X6

    RNA

    1. XR_945594.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      98617284..98641047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364723.1 → XP_054220698.1  protrudin isoform X1

    2. XM_054364724.1 → XP_054220699.1  protrudin isoform X2

    3. XM_054364727.1 → XP_054220702.1  protrudin isoform X5

    4. XM_054364725.1 → XP_054220700.1  protrudin isoform X3

    5. XM_054364726.1 → XP_054220701.1  protrudin isoform X4

    6. XM_054364728.1 → XP_054220703.1  protrudin isoform X6

    RNA

    1. XR_008488162.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5T4F4.1 GenPept UniProtKB/Swiss-Prot:Q5T4F4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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