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    AVPI1 arginine vasopressin induced 1 [ Homo sapiens (human) ]

    Gene ID: 60370, updated on 27-Nov-2024

    Summary

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    Official Symbol
    AVPI1provided by HGNC
    Official Full Name
    arginine vasopressin induced 1provided by HGNC
    Primary source
    HGNC:HGNC:30898
    See related
    Ensembl:ENSG00000119986 MIM:618537; AllianceGenome:HGNC:30898
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VIP32; VIT32; PP5395
    Summary
    Predicted to be involved in positive regulation of MAPK cascade. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal (RPKM 14.7), colon (RPKM 12.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See AVPI1 in Genome Data Viewer
    Location:
    10q24.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (97677424..97687241, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (98557625..98567393, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (99437181..99446998, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene MORN repeat containing 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3854 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:99399170-99399353 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2683 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3855 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3856 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:99411103-99412302 Neighboring gene phosphatidylinositol 4-kinase type 2 alpha Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99435535-99436034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3857 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:99446822-99448021 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2685 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:99478816-99479636 Neighboring gene MARVEL domain containing 1 Neighboring gene Sharpr-MPRA regulatory region 11334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3859 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2686 Neighboring gene zinc finger FYVE-type containing 27 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2687 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99519797-99520296

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. AVP-induced VIT32 gene expression in collecting duct cells occurs via trans-activation of a CRE in the 5'-flanking region of the VIT32 gene. Thomas CP, et al. Am J Physiol Renal Physiol, 2004 Sep. PMID 15140762
    2. A novel vasopressin-induced transcript promotes MAP kinase activation and ENaC downregulation. Nicod M, et al. EMBO J, 2002 Oct 1. PMID 12356727, Free PMC Article
    3. Expanding the substantial interactome of NEMO using protein microarrays. Fenner BJ, et al. PLoS One, 2010 Jan 20. PMID 20098747, Free PMC Article
    4. Large-scale cDNA transfection screening for genes related to cancer development and progression. Wan D, et al. Proc Natl Acad Sci U S A, 2004 Nov 2. PMID 15498874, Free PMC Article
    5. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. Virok DP, et al. J Proteome Res, 2011 Apr 1. PMID 21244100

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    arginine vasopressin-induced protein 1
    Names
    AVP-induced protein 1
    vasopressin-induced transcript

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021732.3 → NP_068378.2  arginine vasopressin-induced protein 1

      See identical proteins and their annotated locations for NP_068378.2

      Status: VALIDATED

      Source sequence(s)
      AL355315
      Consensus CDS
      CCDS7470.1
      UniProtKB/Swiss-Prot
      Q53G32, Q5T686, Q9H2R9, Q9HBN9
      Related
      ENSP00000359660.3, ENST00000370626.4
      Conserved Domains (1) summary
      pfam15063
      Location:2 → 70
      TC1; Thyroid cancer protein 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      97677424..97687241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016494.2 → XP_016871983.1  arginine vasopressin-induced protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q53G32, Q5T686, Q9H2R9, Q9HBN9
      Conserved Domains (1) summary
      pfam15063
      Location:2 → 70
      TC1; Thyroid cancer protein 1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      98557625..98567393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366513.1 → XP_054222488.1  arginine vasopressin-induced protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q53G32, Q5T686, Q9H2R9, Q9HBN9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5T686.3 GenPept UniProtKB/Swiss-Prot:Q5T686

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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