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    NTNG2 netrin G2 [ Homo sapiens (human) ]

    Gene ID: 84628, updated on 27-Nov-2024

    Summary

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    Official Symbol
    NTNG2provided by HGNC
    Official Full Name
    netrin G2provided by HGNC
    Primary source
    HGNC:HGNC:14288
    See related
    Ensembl:ENSG00000196358 MIM:618689; AllianceGenome:HGNC:14288
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Lmnt2; NTNG1; NEDBASH; LHLL9381; NetrinG2; bA479K20.1
    Summary
    Predicted to be involved in axonogenesis; regulation of cell projection organization; and regulation of neuron migration. Predicted to be located in plasma membrane. Predicted to be active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and presynaptic active zone membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bone marrow (RPKM 7.5), brain (RPKM 4.1) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NTNG2 in Genome Data Viewer
    Location:
    9q34.13
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (132161689..132244526)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (144375733..144459025)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (135037445..135119913)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134752115-134752615 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134764767-134765298 Neighboring gene Sharpr-MPRA regulatory region 801 Neighboring gene mediator complex subunit 27 Neighboring gene NANOG hESC enhancer GRCh37_chr9:134840462-134840963 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:134843516-134843723 Neighboring gene MPRA-validated peak7336 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:134882251-134882943 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134915689-134916190 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:134917173-134918372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134916191-134916690 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:134951028-134952227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29216 Neighboring gene uncharacterized LOC105376302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:135004636-135005136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:135005137-135005637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:135011939-135012452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:135029860-135030360 Neighboring gene uncharacterized LOC124902291 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:135044919-135045676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:135045677-135046434 Neighboring gene Sharpr-MPRA regulatory region 1592 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:135061794-135062407 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:135082729-135083404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:135083405-135084080 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:135089048-135089792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:135115111-135115628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:135120407-135120912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:135120913-135121418 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:135144739-135145938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:135171222-135171722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:135171723-135172223 Neighboring gene senataxin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29217 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:135229958-135231157 Neighboring gene Sharpr-MPRA regulatory region 6614 Neighboring gene uncharacterized LOC124902292 Neighboring gene transcription termination factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Homozygous Missense Variants in NTNG2, Encoding a Presynaptic Netrin-G2 Adhesion Protein, Lead to a Distinct Neurodevelopmental Disorder. Dias CM, et al. Am J Hum Genet, 2019 Nov 7. PMID 31668703, Free PMC Article
    2. Homozygous frameshift variant in NTNG2, encoding a synaptic cell adhesion molecule, in individuals with developmental delay, hypotonia, and autistic features. Abu-Libdeh B, et al. Neurogenetics, 2019 Oct. PMID 31372774
    3. Crystal structure of the ligand binding domain of netrin G2. Brasch J, et al. J Mol Biol, 2011 Dec 16. PMID 22041449, Free PMC Article
    4. A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia. Aoki-Suzuki M, et al. Biol Psychiatry, 2005 Feb 15. PMID 15705354
    5. Human netrin-G1 isoforms show evidence of differential expression. Meerabux JM, et al. Genomics, 2005 Jul. PMID 15901489

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Netrin-G2 dysfunction causes a Rett-like phenotype with areflexia.
      Title: Netrin-G2 dysfunction causes a Rett-like phenotype with areflexia.
    2. Homozygous frameshift variant in NTNG2, encoding a synaptic cell adhesion molecule, in individuals with developmental delay, hypotonia, and autistic features.
      Title: Homozygous frameshift variant in NTNG2, encoding a synaptic cell adhesion molecule, in individuals with developmental delay, hypotonia, and autistic features.
    3. Appropriate expression of NTNG2 plays an important role in neurotypical development.
      Title: Homozygous Missense Variants in NTNG2, Encoding a Presynaptic Netrin-G2 Adhesion Protein, Lead to a Distinct Neurodevelopmental Disorder.
    4. presence of Gng2 and Netrin-G2 immunoreactive elements in the insular cortex, but not in the putamen, suggests a possible common ontogeny of the claustrum and insula
      Title: Topography of Gng2- and NetrinG2-expression suggests an insular origin of the human claustrum.
    5. the crystal structure for a fragment comprising the LN domain and domain LE1 of netrin G2 by sulfur single-wavelength anomalous diffraction phasing and refined it to 1.8 A resolution was determined.
      Title: Crystal structure of the ligand binding domain of netrin G2.
    6. Netrin-g2 is involved in the pathophysiology of epilepsy and are consistent with the hypothesis that this protein may participate in the abnormal development of synapses and in neuron migration
      Title: Abnormal expression of netrin-G2 in temporal lobe epilepsy neurons in humans and a rat model.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters.
    8. The data of this stusty implicate NTNG2 in the pathophysiology of schizophrenia and bipolar disorder, but do not support the hypothesis that altered mRNA expression is the mechanism by which genetic variation of NTNG2 may confer disease susceptibility.
      Title: Decreased mRNA expression of netrin-G1 and netrin-G2 in the temporal lobe in schizophrenia and bipolar disorder.
    9. An association between NTNG2 and schizophrenia was observed with SNPs and haplotypes that clustered in the 5' region of the gene.
      Title: A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Neurodevelopmental disorder with behavioral abnormalities, absent speech, and hypotonia
    MedGen: C5231471 OMIM: 618718 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0625, KIAA1857, MGC21884

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in postsynaptic specialization assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of neuron projection arborization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of presynapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic membrane adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in presynaptic active zone membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    netrin-G2
    Names
    laminet 2
    netrin G1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032536.4 → NP_115925.2  netrin-G2 precursor

      See identical proteins and their annotated locations for NP_115925.2

      Status: VALIDATED

      Source sequence(s)
      AL159997, AL353631, CK301008
      Consensus CDS
      CCDS6946.1
      UniProtKB/Swiss-Prot
      Q5JUJ2, Q6UXY0, Q96CW9, Q96JH0
      Related
      ENSP00000376921.3, ENST00000393229.4
      Conserved Domains (3) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:409 → 456
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      132161689..132244526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519096.3 → XP_011517398.1  netrin-G2 isoform X1

      See identical proteins and their annotated locations for XP_011517398.1

      Conserved Domains (4) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:515 → 562
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:562 → 592
      EGF_2; EGF-like domain

    2. XM_017015213.2 → XP_016870702.1  netrin-G2 isoform X1

      Conserved Domains (4) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:515 → 562
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:562 → 592
      EGF_2; EGF-like domain

    3. XM_047423970.1 → XP_047279926.1  netrin-G2 isoform X1

    4. XM_017015212.2 → XP_016870701.1  netrin-G2 isoform X1

      Conserved Domains (4) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:515 → 562
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:562 → 592
      EGF_2; EGF-like domain

    5. XM_011519094.3 → XP_011517396.1  netrin-G2 isoform X1

      See identical proteins and their annotated locations for XP_011517396.1

      Conserved Domains (4) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:515 → 562
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:562 → 592
      EGF_2; EGF-like domain

    6. XM_011519106.3 → XP_011517408.1  netrin-G2 isoform X2

      Conserved Domains (4) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:492 → 539
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:539 → 569
      EGF_2; EGF-like domain

    7. XM_006717304.4 → XP_006717367.1  netrin-G2 isoform X3

      Conserved Domains (4) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:443 → 490
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:490 → 520
      EGF_2; EGF-like domain

    8. XM_011519107.3 → XP_011517409.1  netrin-G2 isoform X4

      See identical proteins and their annotated locations for XP_011517409.1

      UniProtKB/Swiss-Prot
      Q5JUJ2, Q6UXY0, Q96CW9, Q96JH0
      Conserved Domains (3) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:409 → 456
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)

    9. XM_011519098.3 → XP_011517400.1  netrin-G2 isoform X1

      See identical proteins and their annotated locations for XP_011517400.1

      Conserved Domains (4) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:515 → 562
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:562 → 592
      EGF_2; EGF-like domain

    10. XM_011519102.3 → XP_011517404.1  netrin-G2 isoform X1

      See identical proteins and their annotated locations for XP_011517404.1

      Conserved Domains (4) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:515 → 562
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:562 → 592
      EGF_2; EGF-like domain

    11. XM_011519097.4 → XP_011517399.1  netrin-G2 isoform X1

      See identical proteins and their annotated locations for XP_011517399.1

      Conserved Domains (4) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:515 → 562
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:562 → 592
      EGF_2; EGF-like domain

    12. XM_011519099.3 → XP_011517401.1  netrin-G2 isoform X1

      See identical proteins and their annotated locations for XP_011517401.1

      Conserved Domains (4) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:515 → 562
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:562 → 592
      EGF_2; EGF-like domain

    13. XM_011519100.3 → XP_011517402.1  netrin-G2 isoform X1

      See identical proteins and their annotated locations for XP_011517402.1

      Conserved Domains (4) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:515 → 562
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:562 → 592
      EGF_2; EGF-like domain

    14. XM_011519108.3 → XP_011517410.1  netrin-G2 isoform X5

      Conserved Domains (2) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)

    15. XM_011519109.3 → XP_011517411.1  netrin-G2 isoform X6

      Conserved Domains (2) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)

    16. XM_011519110.3 → XP_011517412.1  netrin-G2 isoform X7

      Conserved Domains (2) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)

    17. XM_017015216.2 → XP_016870705.1  netrin-G2 isoform X9

    18. XM_011519105.3 → XP_011517407.1  netrin-G2 isoform X1

      See identical proteins and their annotated locations for XP_011517407.1

      Conserved Domains (4) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:515 → 562
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:562 → 592
      EGF_2; EGF-like domain

    19. XM_047423971.1 → XP_047279927.1  netrin-G2 isoform X1

    20. XM_011519104.4 → XP_011517406.1  netrin-G2 isoform X1

      See identical proteins and their annotated locations for XP_011517406.1

      Conserved Domains (4) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:515 → 562
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:562 → 592
      EGF_2; EGF-like domain

    21. XM_011519103.3 → XP_011517405.1  netrin-G2 isoform X1

      See identical proteins and their annotated locations for XP_011517405.1

      Conserved Domains (4) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:515 → 562
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:562 → 592
      EGF_2; EGF-like domain

    22. XM_011519112.3 → XP_011517414.1  netrin-G2 isoform X8

      Conserved Domains (1) summary
      pfam00053
      Location:184 → 231
      Laminin_EGF; Laminin EGF domain

    23. XM_011519113.3 → XP_011517415.1  netrin-G2 isoform X10

      Conserved Domains (1) summary
      pfam00053
      Location:161 → 208
      Laminin_EGF; Laminin EGF domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      144375733..144459025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363989.1 → XP_054219964.1  netrin-G2 isoform X1

    2. XM_054363993.1 → XP_054219968.1  netrin-G2 isoform X1

    3. XM_054363994.1 → XP_054219969.1  netrin-G2 isoform X1

    4. XM_054363988.1 → XP_054219963.1  netrin-G2 isoform X1

    5. XM_054363986.1 → XP_054219961.1  netrin-G2 isoform X1

    6. XM_054364000.1 → XP_054219975.1  netrin-G2 isoform X2

    7. XM_054364002.1 → XP_054219977.1  netrin-G2 isoform X12

    8. XM_054364001.1 → XP_054219976.1  netrin-G2 isoform X11

    9. XM_054364003.1 → XP_054219978.1  netrin-G2 isoform X3

    10. XM_054364004.1 → XP_054219979.1  netrin-G2 isoform X4

    11. XM_054363992.1 → XP_054219967.1  netrin-G2 isoform X1

    12. XM_054363995.1 → XP_054219970.1  netrin-G2 isoform X1

    13. XM_054363991.1 → XP_054219966.1  netrin-G2 isoform X1

    14. XM_054363987.1 → XP_054219962.1  netrin-G2 isoform X1

    15. XM_054363990.1 → XP_054219965.1  netrin-G2 isoform X1

    16. XM_054364005.1 → XP_054219980.1  netrin-G2 isoform X5

    17. XM_054364008.1 → XP_054219983.1  netrin-G2 isoform X6

    18. XM_054364010.1 → XP_054219985.1  netrin-G2 isoform X16

    19. XM_054364011.1 → XP_054219986.1  netrin-G2 isoform X7

    20. XM_054364007.1 → XP_054219982.1  netrin-G2 isoform X14

    21. XM_054364012.1 → XP_054219987.1  netrin-G2 isoform X9

    22. XM_054363997.1 → XP_054219972.1  netrin-G2 isoform X1

    23. XM_054363998.1 → XP_054219973.1  netrin-G2 isoform X1

    24. XM_054363999.1 → XP_054219974.1  netrin-G2 isoform X1

    25. XM_054363996.1 → XP_054219971.1  netrin-G2 isoform X1

    26. XM_054364009.1 → XP_054219984.1  netrin-G2 isoform X15

    27. XM_054364006.1 → XP_054219981.1  netrin-G2 isoform X13

    RNA

    1. XR_008488085.1 RNA Sequence

    2. XR_008488084.1 RNA Sequence

    3. XR_008488083.1 RNA Sequence

    4. XR_008488081.1 RNA Sequence

    5. XR_008488082.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96CW9.2 GenPept UniProtKB/Swiss-Prot:Q96CW9

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