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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_053077.1 RefSeqGene
- Range
-
45302..133384
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001139488.2 → NP_001132960.1 ras guanyl-releasing protein 3 isoform 1
See identical proteins and their annotated locations for NP_001132960.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2, and 4-6 all encode the same isoform (1).
- Source sequence(s)
-
AA351079, BC027849, BX647990, DA336406, DA439087
- Consensus CDS
-
CCDS46256.1
- UniProtKB/Swiss-Prot
- D6W583, O94931, Q53SD7, Q8IV61
- UniProtKB/TrEMBL
-
A8KAB8
- Related
- ENSP00000384192.3, ENST00000403687.8
- Conserved Domains (4) summary
-
- cd06224
Location:11 → 126
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
- smart00147
Location:148 → 384
- RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
- pfam13499
Location:428 → 478
- EF-hand_7; EF-hand domain pair
- cd20862
Location:488 → 546
- C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins
-
NM_001349975.2 → NP_001336904.1 ras guanyl-releasing protein 3 isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-6 all encode the same isoform (1).
- Source sequence(s)
-
AC020594
- Consensus CDS
-
CCDS46256.1
- UniProtKB/Swiss-Prot
- D6W583, O94931, Q53SD7, Q8IV61
- UniProtKB/TrEMBL
-
A8KAB8
- Conserved Domains (4) summary
-
- cd06224
Location:11 → 126
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
- smart00147
Location:148 → 384
- RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
- pfam13499
Location:428 → 478
- EF-hand_7; EF-hand domain pair
- cd20862
Location:488 → 546
- C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins
-
NM_001349976.2 → NP_001336905.1 ras guanyl-releasing protein 3 isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-6 all encode the same isoform (1).
- Source sequence(s)
-
AC020594
- Consensus CDS
-
CCDS46256.1
- UniProtKB/Swiss-Prot
- D6W583, O94931, Q53SD7, Q8IV61
- UniProtKB/TrEMBL
-
A8KAB8
- Conserved Domains (4) summary
-
- cd06224
Location:11 → 126
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
- smart00147
Location:148 → 384
- RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
- pfam13499
Location:428 → 478
- EF-hand_7; EF-hand domain pair
- cd20862
Location:488 → 546
- C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins
-
NM_001349977.2 → NP_001336906.1 ras guanyl-releasing protein 3 isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) represents the longest transcript and differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-6 all encode the same isoform (1).
- Source sequence(s)
-
AC020594
- Consensus CDS
-
CCDS46256.1
- UniProtKB/Swiss-Prot
- D6W583, O94931, Q53SD7, Q8IV61
- UniProtKB/TrEMBL
-
A8KAB8
- Conserved Domains (4) summary
-
- cd06224
Location:11 → 126
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
- smart00147
Location:148 → 384
- RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
- pfam13499
Location:428 → 478
- EF-hand_7; EF-hand domain pair
- cd20862
Location:488 → 546
- C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins
-
NM_001349978.2 → NP_001336907.1 ras guanyl-releasing protein 3 isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in an isoform (2) which is 1 aa shorter than isoform 1. Variants 3 and 7-10 all encode the same isoform (2).
- Source sequence(s)
-
AC020594
- Consensus CDS
-
CCDS54346.1
- UniProtKB/TrEMBL
-
A8KAB8
- Conserved Domains (4) summary
-
- cd06224
Location:11 → 126
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
- smart00147
Location:148 → 384
- RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
- cd00029
Location:494 → 543
- C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
- pfam13499
Location:427 → 477
- EF-hand_7; EF-hand domain pair
-
NM_001349979.2 → NP_001336908.1 ras guanyl-releasing protein 3 isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in an isoform (2) which is 1 aa shorter than isoform 1. Variants 3 and 7-10 all encode the same isoform (2).
- Source sequence(s)
-
AC020594
- Consensus CDS
-
CCDS54346.1
- UniProtKB/TrEMBL
-
A8KAB8
- Conserved Domains (4) summary
-
- cd06224
Location:11 → 126
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
- smart00147
Location:148 → 384
- RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
- cd00029
Location:494 → 543
- C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
- pfam13499
Location:427 → 477
- EF-hand_7; EF-hand domain pair
-
NM_001349980.2 → NP_001336909.1 ras guanyl-releasing protein 3 isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (9) differs in the 5' UTR and uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in an isoform (2) which is 1 aa shorter than isoform 1. Variants 3 and 7-10 all encode the same isoform (2).
- Source sequence(s)
-
AC020594
- Consensus CDS
-
CCDS54346.1
- UniProtKB/TrEMBL
-
A8KAB8
- Conserved Domains (4) summary
-
- cd06224
Location:11 → 126
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
- smart00147
Location:148 → 384
- RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
- cd00029
Location:494 → 543
- C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
- pfam13499
Location:427 → 477
- EF-hand_7; EF-hand domain pair
-
NM_001349981.2 → NP_001336910.1 ras guanyl-releasing protein 3 isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (10) uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in an isoform (2) which is 1 aa shorter than isoform 1. Variants 3 and 7-10 all encode the same isoform (2).
- Source sequence(s)
-
AC020594
- Consensus CDS
-
CCDS54346.1
- UniProtKB/TrEMBL
-
A8KAB8
- Related
- ENSP00000520853.1, ENST00000850562.1
- Conserved Domains (4) summary
-
- cd06224
Location:11 → 126
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
- smart00147
Location:148 → 384
- RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
- cd00029
Location:494 → 543
- C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
- pfam13499
Location:427 → 477
- EF-hand_7; EF-hand domain pair
-
NM_015376.3 → NP_056191.1 ras guanyl-releasing protein 3 isoform 2
See identical proteins and their annotated locations for NP_056191.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in an isoform (2) which is 1 aa shorter than isoform 1. Variants 3 and 7-10 all encode the same isoform (2).
- Source sequence(s)
-
AA351079, AB020653, BC027849, BX114300, BX647990
- Consensus CDS
-
CCDS54346.1
- UniProtKB/TrEMBL
-
A8KAB8
- Related
- ENSP00000383917.1, ENST00000407811.5
- Conserved Domains (4) summary
-
- cd06224
Location:11 → 126
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
- smart00147
Location:148 → 384
- RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
- cd00029
Location:494 → 543
- C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
- pfam13499
Location:427 → 477
- EF-hand_7; EF-hand domain pair
-
NM_170672.3 → NP_733772.1 ras guanyl-releasing protein 3 isoform 1
See identical proteins and their annotated locations for NP_733772.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-6 all encode the same isoform (1).
- Source sequence(s)
-
AA351079, AC020594, BC027849, BX647990, DA439087
- Consensus CDS
-
CCDS46256.1
- UniProtKB/Swiss-Prot
- D6W583, O94931, Q53SD7, Q8IV61
- UniProtKB/TrEMBL
-
A8KAB8
- Related
- ENSP00000385886.3, ENST00000402538.8
- Conserved Domains (4) summary
-
- cd06224
Location:11 → 126
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
- smart00147
Location:148 → 384
- RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
- pfam13499
Location:428 → 478
- EF-hand_7; EF-hand domain pair
- cd20862
Location:488 → 546
- C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000002.12 Reference GRCh38.p14 Primary Assembly
- Range
-
33436348..33564731
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_011532746.4 → XP_011531048.1 ras guanyl-releasing protein 3 isoform X1
See identical proteins and their annotated locations for XP_011531048.1
- UniProtKB/Swiss-Prot
- D6W583, O94931, Q53SD7, Q8IV61
- UniProtKB/TrEMBL
-
A8KAB8
- Conserved Domains (4) summary
-
- cd06224
Location:11 → 126
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
- smart00147
Location:148 → 384
- RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
- pfam13499
Location:428 → 478
- EF-hand_7; EF-hand domain pair
- cd20862
Location:488 → 546
- C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins
-
XM_011532748.4 → XP_011531050.2 ras guanyl-releasing protein 3 isoform X1
- UniProtKB/Swiss-Prot
- D6W583, O94931, Q53SD7, Q8IV61
- UniProtKB/TrEMBL
-
A8KAB8
- Conserved Domains (4) summary
-
- cd06224
Location:11 → 126
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
- smart00147
Location:148 → 384
- RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
- pfam13499
Location:428 → 478
- EF-hand_7; EF-hand domain pair
- cd20862
Location:488 → 546
- C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins
-
XM_047443877.1 → XP_047299833.1 ras guanyl-releasing protein 3 isoform X1
- UniProtKB/Swiss-Prot
- D6W583, O94931, Q53SD7, Q8IV61
- UniProtKB/TrEMBL
-
A8KAB8
-
XM_047443879.1 → XP_047299835.1 ras guanyl-releasing protein 3 isoform X2
- UniProtKB/TrEMBL
-
A8KAB8
-
XM_047443878.1 → XP_047299834.1 ras guanyl-releasing protein 3 isoform X2
- UniProtKB/TrEMBL
-
A8KAB8
-
XM_017003761.3 → XP_016859250.1 ras guanyl-releasing protein 3 isoform X1
- UniProtKB/Swiss-Prot
- D6W583, O94931, Q53SD7, Q8IV61
- UniProtKB/TrEMBL
-
A8KAB8
- Conserved Domains (4) summary
-
- cd06224
Location:11 → 126
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
- smart00147
Location:148 → 384
- RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
- pfam13499
Location:428 → 478
- EF-hand_7; EF-hand domain pair
- cd20862
Location:488 → 546
- C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins
Alternate T2T-CHM13v2.0
Genomic
-
NC_060926.1 Alternate T2T-CHM13v2.0
- Range
-
33482495..33610876
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054341297.1 → XP_054197272.1 ras guanyl-releasing protein 3 isoform X1
- UniProtKB/Swiss-Prot
- D6W583, O94931, Q53SD7, Q8IV61
- UniProtKB/TrEMBL
-
A8KAB8
-
XM_054341296.1 → XP_054197271.1 ras guanyl-releasing protein 3 isoform X1
- UniProtKB/Swiss-Prot
- D6W583, O94931, Q53SD7, Q8IV61
- UniProtKB/TrEMBL
-
A8KAB8
-
XM_054341298.1 → XP_054197273.1 ras guanyl-releasing protein 3 isoform X1
- UniProtKB/Swiss-Prot
- D6W583, O94931, Q53SD7, Q8IV61
- UniProtKB/TrEMBL
-
A8KAB8
-
XM_054341300.1 → XP_054197275.1 ras guanyl-releasing protein 3 isoform X2
- UniProtKB/TrEMBL
-
A8KAB8
-
XM_054341299.1 → XP_054197274.1 ras guanyl-releasing protein 3 isoform X2
- UniProtKB/TrEMBL
-
A8KAB8
-
XM_054341295.1 → XP_054197270.1 ras guanyl-releasing protein 3 isoform X1
- UniProtKB/Swiss-Prot
- D6W583, O94931, Q53SD7, Q8IV61
- UniProtKB/TrEMBL
-
A8KAB8