U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GPATCH11 G-patch domain containing 11 [ Homo sapiens (human) ]

    Gene ID: 253635, updated on 9-Dec-2024

    Summary

    Official Symbol
    GPATCH11provided by HGNC
    Official Full Name
    G-patch domain containing 11provided by HGNC
    Primary source
    HGNC:HGNC:26768
    See related
    Ensembl:ENSG00000152133 AllianceGenome:HGNC:26768
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CENPY; CCDC75; CENP-Y
    Summary
    Predicted to enable nucleic acid binding activity. Located in kinetochore. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in fat (RPKM 17.4), testis (RPKM 7.9) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GPATCH11 in Genome Data Viewer
    Location:
    2p22.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (37084518..37099244)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (37091653..37106376)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (37311661..37326387)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene striatin Neighboring gene RNA, U6 small nuclear 577, pseudogene Neighboring gene MPRA-validated peak3656 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr2:37189639-37189834 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11352 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:37230067-37230233 Neighboring gene HEAT repeat containing 5B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15579 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15580 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11354 Neighboring gene ARL14EP pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:37416294-37416819 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:37416820-37417344 Neighboring gene sulfotransferase family 6B member 1 Neighboring gene ribosomal protein L31 pseudogene 16

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ38348

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    G patch domain-containing protein 11
    Names
    centromere protein Y
    coiled-coil domain containing 75
    coiled-coil domain-containing protein 75
    g patch domain-containing protein 11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278505.2NP_001265434.1  G patch domain-containing protein 11 isoform 2

      See identical proteins and their annotated locations for NP_001265434.1

      Status: VALIDATED

      Source sequence(s)
      AC007899
      UniProtKB/TrEMBL
      A0A6Q8JGY2
      Related
      ENSP00000281932.6, ENST00000281932.6
      Conserved Domains (1) summary
      pfam13821
      Location:108155
      DUF4187; Domain of unknown function (DUF4187)
    2. NM_001322249.4NP_001309178.3  G patch domain-containing protein 11 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC007899
      UniProtKB/Swiss-Prot
      A0A0A0MSF9, A8K0D9, B7Z2G4, B8ZZ44, Q8N954
      Conserved Domains (3) summary
      COG5281
      Location:34166
      COG5281; Phage-related minor tail protein [Mobilome: prophages, transposons]
      pfam01585
      Location:74109
      G-patch; G-patch domain
      pfam13821
      Location:201248
      DUF4187; Domain of unknown function (DUF4187)
    3. NM_001371856.3NP_001358785.2  G patch domain-containing protein 11 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC007899
      UniProtKB/Swiss-Prot
      A0A0A0MSF9, A8K0D9, B7Z2G4, B8ZZ44, Q8N954
      Conserved Domains (2) summary
      smart00443
      Location:74117
      G_patch; glycine rich nucleic binding domain
      pfam13821
      Location:223270
      DUF4187; Domain of unknown function (DUF4187)
    4. NM_001371858.3NP_001358787.2  G patch domain-containing protein 11 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC007899
      Consensus CDS
      CCDS1785.4
      UniProtKB/Swiss-Prot
      A0A0A0MSF9, A8K0D9, B7Z2G4, B8ZZ44, Q8N954
      UniProtKB/TrEMBL
      A0A6I8PRS5
      Conserved Domains (2) summary
      pfam01585
      Location:74117
      G-patch; G-patch domain
      pfam13821
      Location:215262
      DUF4187; Domain of unknown function (DUF4187)
    5. NM_001371859.3NP_001358788.2  G patch domain-containing protein 11 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC007899
      Consensus CDS
      CCDS1785.4
      UniProtKB/Swiss-Prot
      A0A0A0MSF9, A8K0D9, B7Z2G4, B8ZZ44, Q8N954
      UniProtKB/TrEMBL
      A0A6I8PRS5
      Conserved Domains (2) summary
      pfam01585
      Location:74117
      G-patch; G-patch domain
      pfam13821
      Location:215262
      DUF4187; Domain of unknown function (DUF4187)
    6. NM_001371860.3NP_001358789.2  G patch domain-containing protein 11 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC007899
      UniProtKB/Swiss-Prot
      A0A0A0MSF9, A8K0D9, B7Z2G4, B8ZZ44, Q8N954
      Conserved Domains (2) summary
      smart00443
      Location:74116
      G_patch; glycine rich nucleic binding domain
      pfam13821
      Location:214261
      DUF4187; Domain of unknown function (DUF4187)
    7. NM_001371861.3NP_001358790.2  G patch domain-containing protein 11 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC007899
      UniProtKB/Swiss-Prot
      A0A0A0MSF9, A8K0D9, B7Z2G4, B8ZZ44, Q8N954
      Conserved Domains (2) summary
      smart00443
      Location:74116
      G_patch; glycine rich nucleic binding domain
      pfam13821
      Location:214261
      DUF4187; Domain of unknown function (DUF4187)
    8. NM_001371862.3NP_001358791.2  G patch domain-containing protein 11 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC007899
      UniProtKB/Swiss-Prot
      A0A0A0MSF9, A8K0D9, B7Z2G4, B8ZZ44, Q8N954
      Conserved Domains (2) summary
      smart00443
      Location:74117
      G_patch; glycine rich nucleic binding domain
      pfam13821
      Location:212259
      DUF4187; Domain of unknown function (DUF4187)
    9. NM_174931.4NP_777591.4  G patch domain-containing protein 11 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC007899, AK095667, AK294697
      Consensus CDS
      CCDS1785.4
      UniProtKB/Swiss-Prot
      A0A0A0MSF9, A8K0D9, B7Z2G4, B8ZZ44, Q8N954
      UniProtKB/TrEMBL
      A0A6I8PRS5
      Related
      ENSP00000501347.1, ENST00000674370.2
      Conserved Domains (2) summary
      pfam01585
      Location:74117
      G-patch; G-patch domain
      pfam13821
      Location:215262
      DUF4187; Domain of unknown function (DUF4187)

    RNA

    1. NR_163986.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007899
    2. NR_163987.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007899

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      37084518..37099244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      37091653..37106376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)