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    cnb1 calcineurin regulatory subunit B [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538786, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cnb1
    Official Full Name
    calcineurin regulatory subunit B
    Primary source
    PomBase:SPCC830.06
    Locus tag
    SPOM_SPCC830.06
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See cnb1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003421.2 (2192091..2193378)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene polynucleotide kinase Grc3 Neighboring gene protein mug128 Neighboring gene ncRNA Neighboring gene NuA4 histone acetyltransferase core complex-Piccolo HAT module linker protein Epl1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNAJ domain-containing protein Psi1 Neighboring gene ER membrane protein DP1/Yop1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Cnb1 involved in cytokinesis in Schizosaccharomyces pombe]. Fan JQ, et al. Yi Chuan, 2013 Aug. PMID 23956092
    2. Paxillin-Mediated Recruitment of Calcineurin to the Contractile Ring Is Required for the Correct Progression of Cytokinesis in Fission Yeast. Martín-García R, et al. Cell Rep, 2018 Oct 16. PMID 30332655
    3. The role of the regulatory subunit of fission yeast calcineurin for in vivo activity and its relevance to FK506 sensitivity. Sio SO, et al. J Biol Chem, 2005 Apr 1. PMID 15657058
    4. Negative feedback regulation of calcineurin-dependent Prz1 transcription factor by the CaMKK-CaMK1 axis in fission yeast. Cisneros-Barroso E, et al. Nucleic Acids Res, 2014 Sep. PMID 25081204, Free PMC Article
    5. Negative functional interaction between cell integrity MAPK pathway and Rho1 GTPase in fission yeast. Viana RA, et al. Genetics, 2013 Oct. PMID 23934882, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cnb1 but not Ppb1 is essential for the activation of calcineurin and that the activated calcineurin is the pharmacological target of the FKBP12-FK506 complex in vivo
      Title: The role of the regulatory subunit of fission yeast calcineurin for in vivo activity and its relevance to FK506 sensitivity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables calcium ion binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables calcium-dependent protein serine/threonine phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcineurin-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of calcineurin complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of calcineurin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    calcineurin regulatory subunit B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      2192091..2193378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023467.3 → NP_588476.1  calcineurin regulatory subunit B [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588476.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9UU93
      Conserved Domains (2) summary
      COG5126
      Location:4 → 163
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:94 → 161
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version

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