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    thf1 C1-5,6,7,8-tetrahydrofolate (THF) synthase, trifunctional enzyme Thf1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541217, updated on 18-Sep-2024

    Summary

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    Official Symbol
    thf1
    Official Full Name
    C1-5,6,7,8-tetrahydrofolate (THF) synthase, trifunctional enzyme Thf1
    Primary source
    PomBase:SPBC839.16
    Locus tag
    SPOM_SPBC839.16
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See thf1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (628002..631710)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene translation elongation factor EF-1 alpha Ef1a-c Neighboring gene FKBP-type peptidyl-prolyl cis-trans isomerase Fkh1 Neighboring gene gfo/idh/mocA family oxidoreductase Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single-stranded DNA binding activity of C1-tetrahydrofolate synthase enzymes. Wahls WP, et al. J Biol Chem, 1993 Nov 15. PMID 8226914
    2. The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability. Calvo IA, et al. iScience, 2021 Nov 19. PMID 34805795, Free PMC Article
    3. Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast. Larochelle M, et al. J Cell Sci, 2019 May 31. PMID 31064814
    4. Expanded Interactome of the Intrinsically Disordered Protein Dss1. Schenstrøm SM, et al. Cell Rep, 2018 Oct 23. PMID 30355493, Free PMC Article
    5. A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response. Ptushkina M, et al. Sci Rep, 2017 Sep 21. PMID 28935859, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables formate-tetrahydrofolate ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methenyltetrahydrofolate cyclohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methenyltetrahydrofolate cyclohydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 10-formyltetrahydrofolate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in folic acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in one-carbon metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tetrahydrofolate interconversion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    C1-5,6,7,8-tetrahydrofolate (THF) synthase, trifunctional enzyme Thf1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      628002..631710
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021162.3 → NP_595256.1  C1-5,6,7,8-tetrahydrofolate (THF) synthase, trifunctional enzyme Thf1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595256.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q8WZJ7
      Conserved Domains (4) summary
      PLN02759
      Location:304 → 937
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:4 → 294
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:4 → 121
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
      pfam02882
      Location:127 → 291
      THF_DHG_CYH_C; Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
    Nucleotide Protein
    Heading Accession and Version

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