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    spn1 mitotic septin Spn1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543516, updated on 18-Sep-2024

    Summary

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    Official Symbol
    spn1
    Official Full Name
    mitotic septin Spn1
    Primary source
    PomBase:SPAC4F10.11
    Locus tag
    SPOM_SPAC4F10.11
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See spn1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (4853040..4855199)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene mannan polymerase complex subunit Mnn9 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene kinetochore protein fta1 Neighboring gene GYF domain protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Septins regulate the equatorial dynamics of the separation initiation network kinase Sid2p and glucan synthases to ensure proper cytokinesis. Zheng S, et al. FEBS J, 2018 Jul. PMID 29722930
    2. Requirements of fission yeast septins for complex formation, localization, and function. An H, et al. Mol Biol Cell, 2004 Dec. PMID 15385632, Free PMC Article
    3. Role of septins and the exocyst complex in the function of hydrolytic enzymes responsible for fission yeast cell separation. Martín-Cuadrado AB, et al. Mol Biol Cell, 2005 Oct. PMID 16079182, Free PMC Article
    4. Septin ring assembly is regulated by Spt20, a structural subunit of the SAGA complex. Lei B, et al. J Cell Sci, 2014 Sep 15. PMID 25015293
    5. The Rho-GEF Gef3 interacts with the septin complex and activates the GTPase Rho4 during fission yeast cytokinesis. Wang N, et al. Mol Biol Cell, 2015 Jan 15. PMID 25411334, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that Rho guanine nucleotide exchange factors Gef3 interacts with the septin complex and activates Rho4 GTPase for septation during cytokinesis.
      Title: The Rho-GEF Gef3 interacts with the septin complex and activates the GTPase Rho4 during fission yeast cytokinesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables GTP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in medial cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in medial cortex septin ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic actomyosin contractile ring, proximal layer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitotic septin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitotic septin Spn1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4853040..4855199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020181.3 → NP_594754.1  mitotic septin Spn1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594754.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O36023, Q09126
      Conserved Domains (3) summary
      cd01850
      Location:92 → 369
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:73 → 459
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam03580
      Location:338 → 461
      Herpes_UL14; Herpesvirus UL14-like protein
    Nucleotide Protein
    Heading Accession and Version

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