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    rad24 14-3-3 protein Rad24 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542029, updated on 30-Oct-2024

    Summary

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    Official Symbol
    rad24
    Official Full Name
    14-3-3 protein Rad24
    Primary source
    PomBase:SPAC8E11.02c
    Locus tag
    SPOM_SPAC8E11.02C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    anr5; sam3; sam4
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    Genomic context

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    See rad24 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (3384227..3385685)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene palmitoyl-(protein) hydrolase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RecA family ATPase Dmc1 Neighboring gene ncRNA Neighboring gene beta-fructofuranosidase Neighboring gene alpha SNAP Neighboring gene U3 snoRNP-associated protein Utp7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In Schizosaccharomyces pombe the 14-3-3 protein Rad24p is involved in negative control of pho1 gene expression. Voicu PM, et al. Yeast, 2007 Feb. PMID 17173334
    2. 14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast. Ford JC, et al. Science, 1994 Jul 22. PMID 8036497
    3. The fission yeast DNA structure checkpoint protein Rad26ATRIP/LCD1/UVSD accumulates in the cytoplasm following microtubule destabilization. Baschal EE, et al. BMC Cell Biol, 2006 Aug 24. PMID 16930478, Free PMC Article
    4. Nuclear exclusion of Cdc25 is not required for the DNA damage checkpoint in fission yeast. Lopez-Girona A, et al. Curr Biol, 2001 Jan 9. PMID 11166180
    5. Members of the Arabidopsis 14-3-3 gene family trans-complement two types of defects in fission yeast. Kuromori T, et al. Plant Sci, 2000 Sep 8. PMID 10996255

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutational analyses of the interacting domains of Schizosaccharomyces pombe Byr2 with 14-3-3s.
      Title: Mutational analyses of the interacting domains of Schizosaccharomyces pombe Byr2 with 14-3-3s.
    2. SIN-dependent phosphorylation of Cdr2 promotes its interaction with the 14-3-3 protein Rad24 that sequesters it in the cytoplasm during cell division.
      Title: SIN-Dependent Dissociation of the SAD Kinase Cdr2 from the Cell Cortex Resets the Division Plane.
    3. The loss of rad24 in ssp1(-) cells reduces the severity of hyperosmotic stress response and relieves mitotic delay.
      Title: Genetic and physical interaction of Ssp1 CaMKK and Rad24 14-3-3 during low pH and osmotic stress in fission yeast.
    4. Identification of sam4 as an allele of rad24.
      Title: Identification of sam4 as a rad24 allele in Schizosaccharomyces pombe.
    5. data presented here show that two elements of fission yeast DNA structure checkpoints, Rad26 and Rad24, define a pathway that responds to microtubule destabilizing conditions
      Title: The fission yeast DNA structure checkpoint protein Rad26ATRIP/LCD1/UVSD accumulates in the cytoplasm following microtubule destabilization.
    6. The 14-3-3 protein Rad24p is involved in negative control of pho1 gene expression in Schizosaccharomyces pombe.
      Title: In Schizosaccharomyces pombe the 14-3-3 protein Rad24p is involved in negative control of pho1 gene expression.
    7. findings demonstrate that G2 arrest induced by HIV-1 Vpr is also associated with increase in phosphorylation & amount of Wee1 in a Chk1/Cds1-independent manner; Rad24 appears to contribute to Vpr-induced G2 arrest by elevating Wee1 expression
      Title: HIV-1 Vpr induces G2 cell cycle arrest in fission yeast associated with Rad24/14-3-3-dependent, Chk1/Cds1-independent Wee1 upregulation.
    8. Rad24p-mediated cytoplasmic retention of Clp1p/Flp1p is important for cell viability upon stress to the cell division apparatus.
      Title: The 14-3-3 protein rad24p modulates function of the cdc14p family phosphatase clp1p/flp1p in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein sequestering activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein sequestering activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to heat EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in mitotic DNA replication checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic G2 DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of induction of conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell division site HDA PubMed 
    is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in mitotic actomyosin contractile ring, distal actin filament layer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle pole body HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    14-3-3 protein Rad24

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3384227..3385685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019591.3 → NP_594167.1  14-3-3 protein Rad24 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594167.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O42704, O42879, P42656
      Conserved Domains (1) summary
      COG5040
      Location:3 → 270
      BMH1; 14-3-3 family protein [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version

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