U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    klp2 kinesin-14 family minus-end directed microtubule motor Klp2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543360, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    klp2
    Official Full Name
    kinesin-14 family minus-end directed microtubule motor Klp2
    Primary source
    PomBase:SPAC664.10
    Locus tag
    SPOM_SPAC664.10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See klp2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (1721954..1724902)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene gamma-glutamyltranspeptidase Ggt1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene chaperone Ssc1 Neighboring gene succinate dehydrogenase assembly factor 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The kinesin-14 Klp2 organizes microtubules into parallel bundles by an ATP-dependent sorting mechanism. Braun M, et al. Nat Cell Biol, 2009 Jun. PMID 19430466
    2. The kinesin Klp2 mediates polarization of interphase microtubules in fission yeast. Carazo-Salas RE, et al. Science, 2005 Jul 8. PMID 16002618
    3. Klp2 and Ase1 synergize to maintain meiotic spindle stability during metaphase I. Zheng F, et al. J Biol Chem, 2020 Sep 18. PMID 32723864, Free PMC Article
    4. Crosslinkers and motors organize dynamic microtubules to form stable bipolar arrays in fission yeast. Janson ME, et al. Cell, 2007 Jan 26. PMID 17254972
    5. Mitotic chromosome biorientation in fission yeast is enhanced by dynein and a minus-end-directed, kinesin-like protein. Grishchuk EL, et al. Mol Biol Cell, 2007 Jun. PMID 17409356, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Force by minus-end motors Dhc1 and Klp2 collapses the S. pombe spindle after laser ablation.
      Title: Force by minus-end motors Dhc1 and Klp2 collapses the S. pombe spindle after laser ablation.
    2. The Putative RNA-Binding Protein Dri1 Promotes the Loading of Kinesin-14/Klp2 to the Mitotic Spindle and Is Sequestered into Heat-Induced Protein Aggregates in Fission Yeast.
      Title: The Putative RNA-Binding Protein Dri1 Promotes the Loading of Kinesin-14/Klp2 to the Mitotic Spindle and Is Sequestered into Heat-Induced Protein Aggregates in Fission Yeast.
    3. Klp2 and Ase1 synergize to maintain meiotic spindle stability during metaphase I.
      Title: Klp2 and Ase1 synergize to maintain meiotic spindle stability during metaphase I.
    4. treatment with a microtubule-destabilizing drug not only suppresses cut7 temperature sensitivity but also rescues the lethality resulting from the deletion of cut7, though a single klp2 deletion per se cannot compensate for the loss of Cut7.
      Title: Suppressor Analysis Uncovers That MAPs and Microtubule Dynamics Balance with the Cut7/Kinesin-5 Motor for Mitotic Spindle Assembly in Schizosaccharomyces pombe.
    5. although deletion of either pkl1 or klp2 rescues temperature-sensitive cut7 mutants, deletion of only pkl1 can bypass the lethality caused by cut7 deletion
      Title: Two spatially distinct kinesin-14 proteins, Pkl1 and Klp2, generate collaborative inward forces against kinesin-5 Cut7 in S. pombe.
    6. Klp2-dependent nuclear congression proceeds at constant speed, whereas dynein accumulation results in an increase of nuclear velocity over time.
      Title: Microtubule minus end motors kinesin-14 and dynein drive nuclear congression in parallel pathways.
    7. We observe SIN-dependent disappearance of Klp2 from MTs in anaphase, and we find that this is mediated by direct phosphorylation of Klp2 by the SIN kinase Sid2, which abrogates loading of Klp2 onto MTs by inhibiting its interaction with Mal3
      Title: The kinesin-14 Klp2 is negatively regulated by the SIN for proper spindle elongation and telophase nuclear positioning.
    8. Data indicate that Klp2 is required for the proper organization of S. pombe interphase microtubules into bipolar arrays of parallel-overlapped microtubules, suggesting that kinesin-14-dependent microtubule sorting may have wide biological importance.
      Title: The kinesin-14 Klp2 organizes microtubules into parallel bundles by an ATP-dependent sorting mechanism.
    9. Sister kinetochore recapture in fission yeast occurs by two distinct mechanisms, both requiring Dam1 and Klp2.
      Title: Sister kinetochore recapture in fission yeast occurs by two distinct mechanisms, both requiring Dam1 and Klp2.
    10. The polarized distribution of interphase microtubules is mediated by the kinesin Klp2, which helps microtubules to become properly organized with plus ends mostly oriented toward the cell ends and minus ends toward the cell center. [klp2]
      Title: The kinesin Klp2 mediates polarization of interphase microtubules in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables minus-end-directed microtubule motor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of microtubule cytoskeleton polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in karyogamy involved in conjugation with cellular fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in meiotic centromere clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic spindle formation (spindle phase two) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule anchoring at mitotic spindle pole body IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in microtubule bundle formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule sliding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in minus-end directed microtubule sliding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic metaphase chromosome recapture IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle formation (spindle phase two) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle midzone assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic spindle organization EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in nuclear migration during mitotic telophase IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nuclear migration involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plus-end directed microtubule sliding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in astral microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cortical microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in meiotic spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule cytoskeleton HDA PubMed 
    is_active_in microtubule minus-end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of minus-end kinesin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle polar microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT is_active_in mitotic spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in polar microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    kinesin-14 family minus-end directed microtubule motor Klp2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1721954..1724902
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018891.3 → NP_593458.1  kinesin-14 family minus-end directed microtubule motor Klp2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593458.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9US03
      Conserved Domains (5) summary
      cd01366
      Location:471 → 809
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      pfam00225
      Location:479 → 807
      Kinesin; Kinesin motor domain
      pfam12709
      Location:309 → 399
      Kinetocho_Slk19; Central kinetochore-associated
      pfam13851
      Location:291 → 470
      GAS; Growth-arrest specific micro-tubule binding
      pfam16796
      Location:452 → 480
      Microtub_bd; Microtubule binding
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials