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    alp1 tubulin-specific chaperone cofactor D Alp1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539669, updated on 18-Sep-2024

    Summary

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    Official Symbol
    alp1
    Official Full Name
    tubulin-specific chaperone cofactor D Alp1
    Primary source
    PomBase:SPBC11C11.04c
    Locus tag
    SPOM_SPBC11C11.04C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    tsm1
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    Genomic context

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    See alp1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003423.3 (3353046..3357047, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene ncRNA Neighboring gene protein Ndc80 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene KRE9-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tubulin heterodimers remain functional for one cell cycle after the inactivation of tubulin-folding cofactor D in fission yeast cells. Fedyanina OS, et al. Yeast, 2009 Apr. PMID 19330768, Free PMC Article
    2. Essential role of tubulin-folding cofactor D in microtubule assembly and its association with microtubules in fission yeast. Hirata D, et al. EMBO J, 1998 Feb 2. PMID 9450991, Free PMC Article
    3. The dual role of fission yeast Tbc1/cofactor C orchestrates microtubule homeostasis in tubulin folding and acts as a GAP for GTPase Alp41/Arl2. Mori R, et al. Mol Biol Cell, 2013 Jun. PMID 23576550, Free PMC Article
    4. Chromosome segregation in fission yeast with mutations in the tubulin folding cofactor D. Fedyanina OS, et al. Curr Genet, 2006 Nov. PMID 17004072
    5. A conserved small GTP-binding protein Alp41 is essential for the cofactor-dependent biogenesis of microtubules in fission yeast. Radcliffe PA, et al. FEBS Lett, 2000 Feb 18. PMID 10683446

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. When cofactor D function is perturbed in cells blocked in G(2), cytoplasmic microtubules appear normal for 2-3 h but thereafter they disintegrate quickly, so that only a few short MTs remain.
      Title: Tubulin heterodimers remain functional for one cell cycle after the inactivation of tubulin-folding cofactor D in fission yeast cells.
    2. Chromosome segregation in fission yeast with mutations in the tubulin folding cofactor
      Title: Chromosome segregation in fission yeast with mutations in the tubulin folding cofactor D.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein folding chaperone EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-chaperonin tubulin folding pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tubulin complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell division site HDA PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle HDA PubMed 
    is_active_in nucleus HDA PubMed 
    part_of tubulin folding cofactor complex NAS
    Non-traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    tubulin-specific chaperone cofactor D Alp1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3353046..3357047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022314.3 → NP_596393.2  tubulin-specific chaperone cofactor D Alp1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596393.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P78749, Q10197
      Conserved Domains (1) summary
      COG5234
      Location:13 → 1105
      CIN1; Beta-tubulin folding cofactor D [Posttranslational modification, protein turnover, chaperones / Cytoskeleton]
    Nucleotide Protein
    Heading Accession and Version

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