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    ade8 adenylosuccinate lyase Ade8 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539985, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ade8
    Official Full Name
    adenylosuccinate lyase Ade8
    Primary source
    PomBase:SPBC14F5.09c
    Locus tag
    SPOM_SPBC14F5.09C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See ade8 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (4172822..4175500, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ubiquitin ligase Doa10 Neighboring gene ncRNA Neighboring gene mediator complex subunit Med7 Neighboring gene ubiquitin-protein ligase E3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene sorting nexin Snx41

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two purine biosynthetic enzymes that are required for cadmium tolerance in Schizosaccharomyces pombe utilize cysteine sulfinate in vitro. Juang RH, et al. Arch Biochem Biophys, 1993 Aug 1. PMID 8346915
    2. Caffeine-resistance in S. pombe: mutations in three novel caf genes increase caffeine tolerance and affect radiation sensitivity, fertility, and cell cycle. Benko Z, et al. Curr Genet, 1997 Jun. PMID 9211790
    3. Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways. Das J, et al. Sci Signal, 2013 May 21. PMID 23695164, Free PMC Article
    4. Expanded Interactome of the Intrinsically Disordered Protein Dss1. Schenstrøm SM, et al. Cell Rep, 2018 Oct 23. PMID 30355493, Free PMC Article
    5. Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome. Telekawa C, et al. Nucleic Acids Res, 2018 Nov 30. PMID 30321377, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' AMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' AMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 'de novo' IMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    adenylosuccinate lyase Ade8

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      4172822..4175500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022661.3 → NP_596735.1  adenylosuccinate lyase Ade8 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596735.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O60105
      Conserved Domains (2) summary
      cd03302
      Location:11 → 449
      Adenylsuccinate_lyase_2; Adenylsuccinate lyase (ASL)_subgroup 2
      COG0015
      Location:11 → 460
      PurB; Adenylosuccinate lyase [Nucleotide transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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