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    rik1 CLRC ubiquitin ligase complex WD repeat protein Rik1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539050, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rik1
    Official Full Name
    CLRC ubiquitin ligase complex WD repeat protein Rik1
    Primary source
    PomBase:SPCC11E10.08
    Locus tag
    SPOM_SPCC11E10.08
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See rik1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (1467882..1471912)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene translation initiation factor eIF2B alpha subunit Gcn3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene alpha-amylase-like protein Neighboring gene 5S ribosomal RNA Neighboring gene ncRNA Neighboring gene tRNA-Lys

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The fission yeast heterochromatin protein Rik1 is required for telomere clustering during meiosis. Tuzon CT, et al. J Cell Biol, 2004 Jun 21. PMID 15197176, Free PMC Article
    2. Distinct centromere domain structures with separate functions demonstrated in live fission yeast cells. Appelgren H, et al. J Cell Sci, 2003 Oct 1. PMID 12928332
    3. Ubiquitin ligase component Cul4 associates with Clr4 histone methyltransferase to assemble heterochromatin. Jia S, et al. Nat Cell Biol, 2005 Oct. PMID 16127433
    4. Two novel proteins, dos1 and dos2, interact with rik1 to regulate heterochromatic RNA interference and histone modification. Li F, et al. Curr Biol, 2005 Aug 23. PMID 16040243
    5. Set3 contributes to heterochromatin integrity by promoting transcription of subunits of Clr4-Rik1-Cul4 histone methyltransferase complex in fission yeast. Yu Y, et al. Sci Rep, 2016 Aug 19. PMID 27538348, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. characterization of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon) [Dos2 & Rik1]
      Title: Coordination of DNA replication and histone modification by the Rik1-Dos2 complex.
    2. Thus the association of a DCAF, Raf1, with its adaptor, Rik1, is required for histone methylation and to allow RNAi to signal to chromatin
      Title: Raf1 Is a DCAF for the Rik1 DDB1-like protein and has separable roles in siRNA generation and chromatin modification.
    3. Components of the Clr4 histone K3-K9 methyltransferase-Rik1-Cullin4 complex act concertedly at an early step in heterochromatin formation.
      Title: A cullin E3 ubiquitin ligase complex associates with Rik1 and the Clr4 histone H3-K9 methyltransferase and is required for RNAi-mediated heterochromatin formation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic telomere tethering at nuclear periphery IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear polyadenylation-dependent antisense transcript catabolic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in pericentric heterochromatin formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in siRNA-mediated heterochromatin formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in silent mating-type cassette heterochromatin formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in subtelomeric heterochromatin formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    NOT involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CLRC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mating-type region heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in rDNA heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in subtelomeric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CLRC ubiquitin ligase complex WD repeat protein Rik1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1467882..1471912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023194.3 → NP_588204.1  CLRC ubiquitin ligase complex WD repeat protein Rik1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588204.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10426, Q9USN9, Q9UUL7
      Conserved Domains (2) summary
      pfam03178
      Location:712 → 999
      CPSF_A; CPSF A subunit region
      pfam10433
      Location:73 → 512
      MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term
    Nucleotide Protein
    Heading Accession and Version

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