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    ccq1 shelterin complex HEAT repeat subunit Ccq1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539352, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ccq1
    Official Full Name
    shelterin complex HEAT repeat subunit Ccq1
    Primary source
    PomBase:SPCC188.07
    Locus tag
    SPOM_SPCC188.07
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See ccq1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (1486140..1488678)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene signal recognition particle subunit Srp54 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ubiquitin hydrolase Ubp5 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fission yeast Ccq1 is telomerase recruiter and local checkpoint controller. Tomita K, et al. Genes Dev, 2008 Dec 15. PMID 19141478, Free PMC Article
    2. Shelterin and subtelomeric DNA sequences control nucleosome maintenance and genome stability. van Emden TS, et al. EMBO Rep, 2019 Jan. PMID 30420521, Free PMC Article
    3. Ccq1 restrains Mre11-mediated degradation to distinguish short telomeres from double-strand breaks. Audry J, et al. Nucleic Acids Res, 2024 Apr 24. PMID 38321948, Free PMC Article
    4. An SMC-domain protein in fission yeast links telomeres to the meiotic centrosome. Flory MR, et al. Mol Cell, 2004 Nov 19. PMID 15546621
    5. Ccq1-Raf2 interaction mediates CLRC recruitment to establish heterochromatin at telomeres. Shi S, et al. Life Sci Alliance, 2021 Nov. PMID 34493579, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ccq1 restrains Mre11-mediated degradation to distinguish short telomeres from double-strand breaks.
      Title: Ccq1 restrains Mre11-mediated degradation to distinguish short telomeres from double-strand breaks.
    2. Ccq1-Raf2 interaction mediates CLRC recruitment to establish heterochromatin at telomeres.
      Title: Ccq1-Raf2 interaction mediates CLRC recruitment to establish heterochromatin at telomeres.
    3. We propose that Ccq1 and fragile subtelomeres co-evolved to regulate telomere plasticity by controlling nucleosome occupancy and genome stability.
      Title: Shelterin and subtelomeric DNA sequences control nucleosome maintenance and genome stability.
    4. Data suggest that telomere maintenance protein Ccq1 (Ccq1)-Est1 recruits telomerase to mediate telomere extension, whilst elongated telomeric DNA recruits Ccq1 with the chromatin-remodelling complexes, which in turn releases telomerase from the telomere.
      Title: Fission yeast Ccq1 is a modulator of telomerase activity.
    5. Together, these data provide a first glimpse into the architectural design of the Ccq1-Tpz1-Poz1 complex and reveals unique interactions that are important in maintaining the Schizosaccharomyces pombe telomere in a non-extendible state.
      Title: Spatial Organization and Molecular Interactions of the Schizosaccharomyces pombe Ccq1-Tpz1-Poz1 Shelterin Complex.
    6. Tpz1-Ccq1 interaction is required for Ccq1 Thr93 phosphorylation and telomerase recruitment.
      Title: Tpz1-Ccq1 and Tpz1-Poz1 interactions within fission yeast shelterin modulate Ccq1 Thr93 phosphorylation and telomerase recruitment.
    7. Tpz1 also participates in the activation of telomeres to the extendible state via its interaction with Ccq1
      Title: Tpz1 controls a telomerase-nonextendible telomeric state and coordinates switching to an extendible state via Ccq1.
    8. data suggest that Ccq1p and condensins Cut3p and Cut14p collaborate to mediate resolution of telomeres in mitosis and regulate intertelomeric clustering during interphase
      Title: Ccq1p and the condensin proteins Cut3p and Cut14p prevent telomere entanglements in the fission yeast Schizosaccharomyces pombe.
    9. The loss of Ccq1 results in progressive telomere shortening and persistent ATR-dependent activation of Chk1
      Title: Fission yeast Ccq1 is telomerase recruiter and local checkpoint controller.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables molecular adaptor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in meiotic chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic telomere clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere capping IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere-telomerase complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromosome, telomeric repeat region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    part_of shelterin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in subtelomeric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of telomere cap complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    shelterin complex HEAT repeat subunit Ccq1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1486140..1488678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023200.3 → NP_588210.1  shelterin complex HEAT repeat subunit Ccq1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588210.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10432
      Conserved Domains (3) summary
      pfam07874
      Location:47 → 97
      DUF1660; Prophage protein (DUF1660)
      pfam11496
      Location:129 → 415
      HDA2-3; Class II histone deacetylase complex subunits 2 and 3
      pfam13863
      Location:520 → 608
      DUF4200; Domain of unknown function (DUF4200)
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials