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    dus4 tRNA dihydrouridine synthase Dus4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538996, updated on 18-Sep-2024

    Summary

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    Official Symbol
    dus4
    Official Full Name
    tRNA dihydrouridine synthase Dus4
    Primary source
    PomBase:SPCC777.15
    Locus tag
    SPOM_SPCC777.15
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See dus4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (1624649..1626267)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene retromer complex subunit Vps35 Neighboring gene ncRNA Neighboring gene serine/threonine protein kinase Prp4 Neighboring gene protein phosphatase regulatory subunit Ekc1 Neighboring gene ncRNA Neighboring gene wtf element Wtf14 Neighboring gene wtf element Wtf15

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcription-wide mapping of dihydrouridine reveals that mRNA dihydrouridylation is required for meiotic chromosome segregation. Finet O, et al. Mol Cell, 2022 Jan 20. PMID 34798057, Free PMC Article
    2. A central role for TOR signalling in a yeast model for juvenile CLN3 disease. Bond ME, et al. Microb Cell, 2015 Nov 11. PMID 28357272, Free PMC Article
    3. A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. Vo TV, et al. Cell, 2016 Jan 14. PMID 26771498, Free PMC Article
    4. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372
    5. Transcription and RNA-processing in fission yeast mitochondria. Schäfer B, et al. RNA, 2005 May. PMID 15811919, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA dihydrouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dihydrouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-dihydrouridine20a synthase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables tRNA-dihydrouridine20b synthase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    tRNA dihydrouridine synthase Dus4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1624649..1626267
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023252.3 → NP_588262.1  tRNA dihydrouridine synthase Dus4 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588262.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74553
      Conserved Domains (2) summary
      COG0042
      Location:19 → 303
      DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
      cd02801
      Location:23 → 250
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    Nucleotide Protein
    Heading Accession and Version

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