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    mit1 SHREC complex ATP-dependent chromatin remodeller Mit1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541336, updated on 18-Sep-2024

    Summary

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    Official Symbol
    mit1
    Official Full Name
    SHREC complex ATP-dependent chromatin remodeller Mit1
    Primary source
    PomBase:SPBP35G2.10
    Locus tag
    SPOM_SPBP35G2.10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See mit1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (982068..986422)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene acetolactate synthase catalytic subunit Neighboring gene TRAMP complex zinc knuckle subunit Air1 Neighboring gene ncRNA Neighboring gene U1 snRNP-associated protein Usp103 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein Nbr1 Neighboring gene ncRNA Neighboring gene subfamily NudF ADP-ribose diphosphatase Ysa1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional gene silencing requires dedicated interaction between HP1 protein Chp2 and chromatin remodeler Mit1. Leopold K, et al. Genes Dev, 2019 May 1. PMID 30808655, Free PMC Article
    2. CHD1 remodelers regulate nucleosome spacing in vitro and align nucleosomal arrays over gene coding regions in S. pombe. Pointner J, et al. EMBO J, 2012 Nov 28. PMID 23103765, Free PMC Article
    3. SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules. Job G, et al. Mol Cell, 2016 Apr 21. PMID 27105116, Free PMC Article
    4. HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms. Motamedi MR, et al. Mol Cell, 2008 Dec 26. PMID 19111658, Free PMC Article
    5. SHREC, an effector complex for heterochromatic transcriptional silencing. Sugiyama T, et al. Cell, 2007 Feb 9. PMID 17289569

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent chromatin remodeler activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosome array spacer activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleosome organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pericentric heterochromatin formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in pericentric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rDNA heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in silent mating-type cassette heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in subtelomeric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SHREC complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of SHREC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in chromosome, telomeric repeat region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in heterochromatin island IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mating-type region heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in rDNA heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in subtelomeric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SHREC complex ATP-dependent chromatin remodeller Mit1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      982068..986422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021292.3 → NP_595385.1  SHREC complex ATP-dependent chromatin remodeller Mit1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595385.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9P793
      Conserved Domains (4) summary
      smart00249
      Location:214 → 268
      PHD; PHD zinc finger
      cd00046
      Location:577 → 720
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:559 → 847
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:870 → 985
      Helicase_C; Helicase conserved C-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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