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    mam2 pheromone p-factor receptor Mam2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541606, updated on 18-Sep-2024

    Summary

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    Official Symbol
    mam2
    Official Full Name
    pheromone p-factor receptor Mam2
    Primary source
    PomBase:SPAC11H11.04
    Locus tag
    SPOM_SPAC11H11.04
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See mam2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (4780688..4781922)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene protein mug162 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein Fta6 Neighboring gene ARP2/3 actin-organizing complex actin-related protein subunit Arp2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Schizosaccharomyces pombe mam2 gene encodes a putative pheromone receptor which has a significant homology with the Saccharomyces cerevisiae Ste2 protein. Kitamura K, et al. EMBO J, 1991 Dec. PMID 1657593, Free PMC Article
    2. One motif to bind them: A small-XXX-small motif affects transmembrane domain 1 oligomerization, function, localization, and cross-talk between two yeast GPCRs. Lock A, et al. Biochim Biophys Acta, 2014 Dec. PMID 25157670
    3. A physiologically required G protein-coupled receptor (GPCR)-regulator of G protein signaling (RGS) interaction that compartmentalizes RGS activity. Croft W, et al. J Biol Chem, 2013 Sep 20. PMID 23900842, Free PMC Article
    4. Interaction between pheromone and its receptor of the fission yeast Schizosaccharomyces pombe examined by a force spectroscopy study. Sasuga S, et al. J Biomed Biotechnol, 2012. PMID 22500108, Free PMC Article
    5. A constitutively active GPCR retains its G protein specificity and the ability to form dimers. Ladds G, et al. Mol Microbiol, 2005 Jan. PMID 15659165

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables mating-type P-factor pheromone receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mating-type factor pheromone receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of pheromone response MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of G protein-coupled receptor homodimeric complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of G protein-coupled receptor homodimeric complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell division site HDA PubMed 
    is_active_in cell tip HDA PubMed 
    is_active_in fungal-type vacuole HDA PubMed 
    is_active_in mating projection membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane of cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pheromone p-factor receptor Mam2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4780688..4781922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020150.3 → NP_594722.1  pheromone p-factor receptor Mam2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594722.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q00619
      Conserved Domains (1) summary
      pfam02116
      Location:20 → 297
      STE2; Fungal pheromone mating factor STE2 GPCR
    Nucleotide Protein
    Heading Accession and Version

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