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    tef5 translation elongation factor EF-1 beta subunit, guanyl-nucleotide exchange factor (eEF1B) [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539275, updated on 18-Sep-2024

    Summary

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    Official Symbol
    tef5
    Official Full Name
    translation elongation factor EF-1 beta subunit, guanyl-nucleotide exchange factor (eEF1B)
    Primary source
    PomBase:SPCC1450.04
    Locus tag
    SPOM_SPCC1450.04
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    efb1
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    Genomic context

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    See tef5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003421.2 (1732751..1733847)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Swr1 complex bromodomain subunit Bdf1 Neighboring gene ncRNA Neighboring gene ribonucleoprotein complex protein Utp502 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mediator complex subunit Med19 Neighboring gene CIA machinery monothiol glutaredoxin Grx3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionarily conserved binding of translationally controlled tumor protein to eukaryotic elongation factor 1B. Wu H, et al. J Biol Chem, 2015 Apr 3. PMID 25635048, Free PMC Article
    2. Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA. Zhang K, et al. Science, 2011 Mar 25. PMID 21436456, Free PMC Article
    3. SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast. Singh NS, et al. Curr Biol, 2011 Dec 6. PMID 22119525, Free PMC Article
    4. Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast. Larochelle M, et al. J Cell Sci, 2019 May 31. PMID 31064814
    5. A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. Vo TV, et al. Cell, 2016 Jan 14. PMID 26771498, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation elongation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translational elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation elongation factor 1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    translation elongation factor EF-1 beta subunit, guanyl-nucleotide exchange factor (eEF1B)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1732751..1733847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023293.3 → NP_588303.1  translation elongation factor EF-1 beta subunit, guanyl-nucleotide exchange factor (eEF1B) [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588303.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74173, Q10249
      Conserved Domains (3) summary
      cd10308
      Location:3 → 63
      GST_C_eEF1b_like; Glutathione S-transferase C-terminal-like, alpha helical domain of eukaryotic translation Elongation Factor 1 beta
      cd00292
      Location:126 → 214
      EF1B; Elongation factor 1 beta (EF1B) guanine nucleotide exchange domain. EF1B catalyzes the exchange of GDP bound to the G-protein, EF1A, for GTP, an important step in the elongation cycle of the protein biosynthesis. EF1A binds to and delivers the aminoacyl ...
      pfam10587
      Location:93 → 116
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
    Nucleotide Protein
    Heading Accession and Version

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