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    cdc12 cytokinetic formin Cdc12 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541603, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cdc12
    Official Full Name
    cytokinetic formin Cdc12
    Primary source
    PomBase:SPAC1F5.04c
    Locus tag
    SPOM_SPAC1F5.04C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See cdc12 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (283344..289200)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein Lhs1 Neighboring gene ncRNA Neighboring gene exocytic docking protein Mso1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene FAD-dependent oxidoreductase Neighboring gene ncRNA Neighboring gene protein disulfide isomerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular mechanism of actin filament elongation by formins. Oosterheert W, et al. Science, 2024 Apr 12. PMID 38603491
    2. Regulation of cytokinesis by the formin cdc12p. Yonetani A, et al. Curr Biol, 2010 Mar 23. PMID 20226666, Free PMC Article
    3. Movement of a cytokinesis factor cdc12p to the site of cell division. Chang F. Curr Biol, 1999 Jul 29-Aug 12. PMID 10469572
    4. Regulation and targeting of the fission yeast formin cdc12p in cytokinesis. Yonetani A, et al. Mol Biol Cell, 2008 May. PMID 18305104, Free PMC Article
    5. The cytokinesis formins from the nematode worm and fission yeast differentially mediate actin filament assembly. Neidt EM, et al. J Biol Chem, 2008 Aug 29. PMID 18577519, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cdk1 phosphorylation of formin Cdc12 antagonizes its interaction with Cdc15 and thereby opposes Cdc12's contractile ring localization. These results are consistent with a general role for Cdk1 in inhibiting cytokinesis until chromosome segregation is complete.
      Title: Cdk1-dependent phosphoinhibition of a formin-F-BAR interaction opposes cytokinetic contractile ring formation.
    2. Cdc12 mechanoregulation facilitates actomyosin ring assembly.
      Title: Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly.
    3. Data indicate that the essential role of profilin is to specifically facilitate formin Cdc12-mediated actin assembly for cytokinesis.
      Title: Fission yeast profilin is tailored to facilitate actin assembly by the cytokinesis formin Cdc12.
    4. this paper defines a short motif within the N terminus of Cdc12 that binds directly to the F-BAR domain of the scaffolding protein Cdc15.
      Title: The F-BAR Cdc15 promotes contractile ring formation through the direct recruitment of the formin Cdc12.
    5. Cdc12 and for3 cooperate in cytokinesis and de novo actin assembly at the division site is predominant for contractile ring formation.
      Title: The formins Cdc12 and For3 cooperate during contractile ring assembly in cytokinesis.
    6. Cdc12 is an efficient nucleator (one filament per approximately 3 Cdc12 dimers) that processively elongates profilin-actin at a moderate rate of 10 subunits s-1 muM-1, but lacks filament-bundling activity.
      Title: The functionally distinct fission yeast formins have specific actin-assembly properties.
    7. cdc12p contributes at least two separable activities: actin assembly and one or more additional functions in cytokinesis initiation
      Title: Regulation of cytokinesis by the formin cdc12p.
    8. Live microscopy of cells expressing Cdc12p fluorescent fusion proteins shows for the first time that Cdc12p localizes to a broad band of 30-50 dynamic nodes, where actin filaments are nucleated in random directions.
      Title: Roles of formin nodes and myosin motor activity in Mid1p-dependent contractile-ring assembly during fission yeast cytokinesis.
    9. Cdc12p can recruit SpTm to actin filaments and SpTm has diverse effects on Cdc12p-mediated actin assembly.
      Title: Role of tropomyosin in formin-mediated contractile ring assembly in fission yeast.
    10. most likely hypotheses to explain the incompatibility of human profilin-I with Cdc12p are differences in interactions with the proline-rich sequences in the FH1 domain of Cdc12p and wider "wings" that interact with actin
      Title: Incompatibility with formin Cdc12p prevents human profilin from substituting for fission yeast profilin: insights from crystal structures of fission yeast profilin.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables F-bar domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament polymerization EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in barbed-end actin filament capping IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic actomyosin contractile ring assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic actomyosin contractile ring assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to mitotic actomyosin contractile ring IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell division site HDA PubMed 
    is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mating projection tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in medial cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in medial cortical node IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic actomyosin contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring, proximal layer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytokinetic formin Cdc12

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      283344..289200
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018269.3 → NP_592869.1  cytokinetic formin Cdc12 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_592869.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10059, Q9UTU0
      Conserved Domains (3) summary
      smart00498
      Location:981 → 1427
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:441 → 638
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:234 → 408
      Drf_GBD; Diaphanous GTPase-binding Domain
    Nucleotide Protein
    Heading Accession and Version

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