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    bip1 ER heat shock protein BiP [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541815, updated on 18-Sep-2024

    Summary

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    Official Symbol
    bip1
    Official Full Name
    ER heat shock protein BiP
    Primary source
    PomBase:SPAC22A12.15c
    Locus tag
    SPOM_SPAC22A12.15C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    bip
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    Genomic context

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    See bip1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (1182693..1185485, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene exosome subunit Rrp40 Neighboring gene BSD domain-containing protein Neighboring gene ncRNA Neighboring gene pig-P phosphatidylinositol N-acetylglucosaminyltransferase subunit Neighboring gene ncRNA Neighboring gene dehydrogenase Neighboring gene ATP-citrate synthase subunit 2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of the BiP gene and identification of an ER retention signal in Schizosaccharomyces pombe. Pidoux AL, et al. EMBO J, 1992 Apr. PMID 1373379, Free PMC Article
    2. The BiP protein and the endoplasmic reticulum of Schizosaccharomyces pombe: fate of the nuclear envelope during cell division. Pidoux AL, et al. J Cell Sci, 1993 Aug. PMID 8227200
    3. The 160 N-terminal residues of calnexin define a novel region supporting viability in Schizosaccharomyces pombe. Hajjar F, et al. Yeast, 2007 Feb. PMID 17230581
    4. P(5A)-type ATPase Cta4p is essential for Ca2+ transport in the endoplasmic reticulum of Schizosaccharomyces pombe. Lustoza AC, et al. PLoS One, 2011. PMID 22132152, Free PMC Article
    5. The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis. Kimmig P, et al. Elife, 2012 Oct 15. PMID 23066505, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IC
    Inferred by Curator
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in IRE1-mediated unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cortical endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of endoplasmic reticulum chaperone complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perinuclear endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ER heat shock protein BiP

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1182693..1185485 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018642.3 → NP_593245.1  ER heat shock protein BiP [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593245.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13906, P36604
      Conserved Domains (2) summary
      cd10241
      Location:35 → 407
      HSPA5-like_NBD; Nucleotide-binding domain of human HSPA5 and similar proteins
      pfam00012
      Location:37 → 641
      HSP70; Hsp70 protein
    Nucleotide Protein
    Heading Accession and Version

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