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    ufd1 Hrd1 ubiquitin ligase complex subunit Ufd1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539623, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ufd1
    Official Full Name
    Hrd1 ubiquitin ligase complex subunit Ufd1
    Primary source
    PomBase:SPBC16A3.09c
    Locus tag
    SPOM_SPBC16A3.09C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See ufd1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003423.3 (4282032..4283614)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mitotic cohesin N-acetyltransferase/DNA polymerase eta Eso1 fusion protein Neighboring gene MBOAT family O-acyltransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein stm1 Neighboring gene protein nrm1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single site suppressors of a fission yeast temperature-sensitive mutant in cdc48 identified by whole genome sequencing. Marinova IN, et al. PLoS One, 2015. PMID 25658828, Free PMC Article
    2. SUMO-targeted ubiquitin ligase activity can either suppress or promote genome instability, depending on the nature of the DNA lesion. Nie M, et al. PLoS Genet, 2017 May. PMID 28475613, Free PMC Article
    3. Concerted action of the ubiquitin-fusion degradation protein 1 (Ufd1) and Sumo-targeted ubiquitin ligases (STUbLs) in the DNA-damage response. Køhler JB, et al. PLoS One, 2013. PMID 24265825, Free PMC Article
    4. Functional Crosstalk between the PP2A and SUMO Pathways Revealed by Analysis of STUbL Suppressor, razor 1-1. Nie M, et al. PLoS Genet, 2016 Jul. PMID 27398807, Free PMC Article
    5. Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast. Burr R, et al. J Biol Chem, 2017 Sep 29. PMID 28821619, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that cdc48 cofactor ufd1 is required for SREBP1/2 cleavage/activation but does not interact with cdc48-rbd2 complex; cdc48-ufd1 is instead required at step prior to rbd2 function, during Golgi localization of dsc1-E3 ligase. (cdc48 = AAA family ATPase cdc48; ufd1 = cdc48-ufd1-npl4 complex component ufd1; dsc1-E3 ligase = ubiquitin-protein ligase E3; SREBP1/2 = sterol regulatory element binding proteins 1/2)
      Title: Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast.
    2. a new signaling mechanism involving dual recruitment by SUMO and ubiquitin for Cdc48-Ufd1-Npl4 functions in maintaining genome stability.
      Title: Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables SUMO binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SREBP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Hrd1p ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RQC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of VCP-NPL4-UFD1 AAA ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Hrd1 ubiquitin ligase complex subunit Ufd1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      4282032..4283614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023801.3 → NP_596780.1  Hrd1 ubiquitin ligase complex subunit Ufd1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596780.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13409, O42915, O60193, Q1MVD5
      Conserved Domains (2) summary
      COG5140
      Location:1 → 341
      UFD1; Ubiquitin fusion-degradation protein [Posttranslational modification, protein turnover, chaperones]
      pfam03152
      Location:32 → 208
      UFD1; Ubiquitin fusion degradation protein UFD1
    Nucleotide Protein
    Heading Accession and Version

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