SEI1 seipin [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SEI1
Official Full Name: seipin
Primary source: SGD:S000004396
Locus tag: YLR404W
See related: AllianceGenome:SGD:S000004396; FungiDB:YLR404W; VEuPathDB:YLR404W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: FLD1
Summary: Involved in lipid droplet formation; protein localization; and regulation of lipid biosynthetic process. Located in cortical endoplasmic reticulum and endoplasmic reticulum membrane. Used to study congenital generalized lipodystrophy and congenital generalized lipodystrophy type 2. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SEI1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (928743..929600)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Seipin concentrates distinct neutral lipids via interactions with their acyl chain carboxyl esters.
Title: Seipin concentrates distinct neutral lipids via interactions with their acyl chain carboxyl esters.
Seipin and Nem1 establish discrete ER subdomains to initiate yeast lipid droplet biogenesis.
Title: Seipin and Nem1 establish discrete ER subdomains to initiate yeast lipid droplet biogenesis.
The negative regulation of sphingolipid synthesis by Saccharomyces cerevisiae seipin is likely an evolutionarily conserved process.
Title: Seipin negatively regulates sphingolipid production at the ER-LD contact site.
Proper droplet formation requires the collaboration of Sei1p and Ldb16.
Title: Dissecting seipin function: the localized accumulation of phosphatidic acid at ER/LD junctions in the absence of seipin is suppressed by Sei1p(ΔNterm) only in combination with Ldb16p.
The Fld1/Ldb16 complex facilitates the establishment of lipid droplet (LD) identity by acting as a diffusion barrier at the endoplasmic reticulum-LD contact sites.
Title: The seipin complex Fld1/Ldb16 stabilizes ER-lipid droplet contact sites.
Seipin has dissectible roles in both promoting early lipid droplet (LD) initiation and in regulating LD morphology.
Title: Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology.
Fld1(seipin)-Ldb16 complex affects phosphatidic acid homeostasis at an lipid droplets-forming subdomain of the nuclear envelope.
Title: Seipin is involved in the regulation of phosphatidic acid metabolism at a subdomain of the nuclear envelope in yeast.
The stability of Ldb16 requires Fld1, as Ldb16 is subjected to ER-associated degradation (ERAD) in the absence of Fld1 but is stabilized when Fld1 is present.
Title: Control of lipid droplet size in budding yeast requires the collaboration between Fld1 and Ldb16.
Deletion of FLD1, encoding seipin, leads to impaired dynamics of lipid droplets and defective lipolysis.
Title: A role for seipin in lipid droplet dynamics and inheritance in yeast.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in lipid droplet formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid droplet organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of sphingolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cortical endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: seipin

NP_013508.3

Seipin involved in lipid droplet (LD) assembly; controls lipid particle morphology, number, and size; promotes initiation of LD formation on the ER; ensures that LDs bud from the ER towards the cytosolic side of the membrane; forms a complex with Ldb16p at ER-LD contact sites, stabilizing these sites; null mutants have localized accumulation of phosphatidic acid (PA) marker proteins; BSCL2, human homolog implicated in congenital lipodystrophy, complements yeast null mutant