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    lub1 WD repeat protein Lub1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541208, updated on 18-Sep-2024

    Summary

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    Official Symbol
    lub1
    Official Full Name
    WD repeat protein Lub1
    Primary source
    PomBase:SPBC887.04c
    Locus tag
    SPOM_SPBC887.04C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See lub1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (3546128..3548563, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ClC chloride channel Neighboring gene ncRNA Neighboring gene Noc2p-Noc3p complex subunit Noc3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RNA-binding protein Cwf29 Neighboring gene sorting nexin Snx3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lub1 participates in ubiquitin homeostasis and stress response via maintenance of cellular ubiquitin contents in fission yeast. Ogiso Y, et al. Mol Cell Biol, 2004 Mar. PMID 14993272, Free PMC Article
    2. Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Dixon SJ, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18931302, Free PMC Article
    3. Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species. Beltrao P, et al. PLoS Biol, 2009 Jun 16. PMID 19547744, Free PMC Article
    4. Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Roguev A, et al. Science, 2008 Oct 17. PMID 18818364, Free PMC Article
    5. Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Stewart EV, et al. Mol Cell, 2011 Apr 22. PMID 21504829, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    WD repeat protein Lub1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3546128..3548563 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022398.3 → NP_596478.2  WD repeat protein Lub1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596478.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94289
      Conserved Domains (5) summary
      COG2319
      Location:2 → 290
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:6 → 286
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08324
      Location:465 → 709
      PUL; PUL domain
      pfam09070
      Location:333 → 442
      PFU; PFU (PLAA family ubiquitin binding)
      sd00039
      Location:60 → 101
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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