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    rpc11 DNA-directed RNA polymerase III complex subunit Rpc11 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541521, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rpc11
    Official Full Name
    DNA-directed RNA polymerase III complex subunit Rpc11
    Primary source
    PomBase:SPAC22A12.05
    Locus tag
    SPOM_SPAC22A12.05
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See rpc11 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (1163049..1163522)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene COP9/signalosome complex subunit Csn4 Neighboring gene ncRNA Neighboring gene 40S ribosomal protein uS8 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene serine hydrolase-like protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Point mutations in the Rpb9-homologous domain of Rpc11 that impair transcription termination by RNA polymerase III. Iben JR, et al. Nucleic Acids Res, 2011 Aug. PMID 21450810, Free PMC Article
    2. Mutations in the RNA polymerase III subunit Rpc11p that decrease RNA 3' cleavage activity increase 3'-terminal oligo(U) length and La-dependent tRNA processing. Huang Y, et al. Mol Cell Biol, 2005 Jan. PMID 15632064, Free PMC Article
    3. Mutation of RNA Pol III subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and disrupts zebrafish digestive development. Yee NS, et al. PLoS Biol, 2007 Nov. PMID 18044988, Free PMC Article
    4. RNA processing factors Swd2.2 and Sen1 antagonize RNA Pol III-dependent transcription and the localization of condensin at Pol III genes. Legros P, et al. PLoS Genet, 2014 Nov. PMID 25392932, Free PMC Article
    5. A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. Vo TV, et al. Cell, 2016 Jan 14. PMID 26771498, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Isolation of Rpc11 mutants from Schizosaccharomyces pombe that cause pol III to readthrough terminators in vivo.
      Title: Point mutations in the Rpb9-homologous domain of Rpc11 that impair transcription termination by RNA polymerase III.
    2. Data indicate that Rpc11p limits RNA 3'-U length and that this significantly restricts pre-tRNAs to a La-independent pathway of maturation in fission yeast.
      Title: Mutations in the RNA polymerase III subunit Rpc11p that decrease RNA 3' cleavage activity increase 3'-terminal oligo(U) length and La-dependent tRNA processing.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in termination of RNA polymerase III transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in termination of RNA polymerase III transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase III complex subunit Rpc11

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1163049..1163522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018632.3 → NP_593235.1  DNA-directed RNA polymerase III complex subunit Rpc11 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593235.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13896
      Conserved Domains (3) summary
      smart00661
      Location:2 → 53
      RPOL9; RNA polymerase subunit 9
      COG1594
      Location:1 → 109
      RPB9; DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]
      cd10509
      Location:63 → 108
      Zn-ribbon_RPC11; C-terminal zinc ribbon domain of RPC11 subunit of RNA polymerase III
    Nucleotide Protein
    Heading Accession and Version

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